What is cladosporium herbarum allergy

Part Description

LP Cladosporium herbarum
Cladosporium is one of the most common colonizers of dying and dead plants and also occurs in various soil types, and on food. This mold is frequently found in uncleaned refrigerators, foodstuffs, on moist window frames, in houses with poor ventilation, with straw roofs, and situated in low, damp areas. It has been isolated from fuel tanks, face creams, paints and textiles.

In the allergic population, sensitisation to moulds may vary from 5 to 30%. The wide range of allergenic proteins in C. herbarum may result in sensitisation and subsequent expression of a range of immune-related diseases. Cladosporium sensitisation is particularly associated with severe or life-threatening asthma.

Upper respiratory symptoms happen with exposure to Cladosporium, but asthma symptoms are more prevalent. Cladosporium may also result in allergic bronchopulmonary cladosporiosis. Copyright Copyright © Phadia AB.Source: ImmunoCap, ImmunoCap

AllFam Allergen List

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Unclassified allergens

83 allergenies from every sources with every routes of exposure found (sorted by allergen name).

Name Links to allergen DBs Source Group Routes of exposure
Act a kiwellin AllergenOnline Actinidia arguta (Hardy kiwi fruit) Plants Ingestion
Act c 5 IUIS AllergenOnline Actinidia chinensis (Gold kiwi fruit) Plants Ingestion
Act d 3 IUIS Actinidia deliciosa (Kiwi fruit) Plants Ingestion
Act d 5 IUIS AllergenOnline Actinidia deliciosa (Kiwi fruit) Plants Ingestion
Act e kiwellin AllergenOnline Actinidia eriantha (Velvet vine) Plants Ingestion
Aed a 3 IUIS AllergenOnline Aedes aegypti (Yellow fever mosquito) Animals Sting, bite
Ana p Tha p 2-like AllergenOnline Anaphe panda (moth) Animals Inhalation
Ani p Ani s like AllergenOnline Anisakis pegreffii (Herring worm) Animals Ingestion
Ani s 10 IUIS AllergenOnline Anisakis simplex (Herring worm) Animals Ingestion
Ani s 11 IUIS AllergenOnline Anisakis simplex (Herring worm) Animals Ingestion
Ani s 12 IUIS AllergenOnline Anisakis simplex (Herring worm) Animals Ingestion
Ani s 14 IUIS AllergenOnline Anisakis simplex (Herring worm) Animals Ingestion
Ani s 7 IUIS AllergenOnline Anisakis simplex (Herring worm) Animals Ingestion
Api m 10 IUIS AllergenOnline Apis mellifera (European honeybee) Animals Sting, bite
Api m icarapin AllergenOnline Apis mellifera (European honeybee) Animals Sting, bite
Asp f 1 IUIS AllergenOnline Aspergillus fumigatus (Neosartorya fumigata) (Mold) Fungi Inhalation
Asp f 34 IUIS AllergenOnline Aspergillus fumigatus (Neosartorya fumigata) (Mold) Fungi Inhalation
Asp f 4 IUIS AllergenOnline Aspergillus fumigatus (Neosartorya fumigata) (Mold) Fungi Inhalation
Asp f 7 IUIS AllergenOnline Aspergillus fumigatus (Neosartorya fumigata) (Mold) Fungi Inhalation
Aspa o 1 IUIS Asparagus officinalis (Asparagus) Plants Ingestion
Bla g 36 kd (pept 1) AllergenOnline Blattella germanica (German cockroach) Animals Inhalation
Cav p 1 IUIS AllergenOnline Cavia porcellus (Guinea pig) Animals Inhalation
Cit s 1 IUIS AllergenOnline Citrus sinensis (Sweet orange) Plants Ingestion
Cla h hydrophobin AllergenOnline Cladosporium herbarum (Davidiella tassiana) (Mold) Fungi Inhalation
Cof a 3 IUIS AllergenOnline Coffea arabica (Arabian coffee) Plants Ingestion; Inhalation
Cop c 1 IUIS AllergenOnline Coprinus comatus (Shaggy mane) Fungi Ingestion; Inhalation
Cop c 5 IUIS Coprinus comatus (Shaggy mane) Fungi Inhalation
Cop c 7 IUIS Coprinus comatus (Shaggy mane) Fungi Inhalation
Cte f 1 IUIS Ctenocephalides felis (Cat flea) Animals Contact
Cur l 1 IUIS Curvularia lunata (Cochliobolus lunatus) (Mold) Fungi Inhalation
Cyn d 23 IUIS Cynodon dactylon (Bermuda grass) Plants Inhalation
Dac g 5 IUIS Dactylis glomerata (Orchard grass) Plants Inhalation
Den n 1 IUIS Dendronephthya nipponica (Red soft Coral) Animals Inhalation
Der f 36 IUIS Dermatophagoides farinae (American home dust mite) Animals Inhalation
Der p 36 IUIS Dermatophagoides pteronyssinus (European home dust mite) Animals Inhalation
Epi p 1 IUIS AllergenOnline Epicoccum purpurascens (Epicoccum nigrum) (Mold) Fungi Inhalation
Eri s 2 IUIS AllergenOnline Eriocheir sinensis (Chinese mitten crab) Animals Ingestion
For t 1 IUIS AllergenOnline Forcipomyia taiwana (Biting midge) Animals Sting, bite
Gad m 2 IUIS AllergenOnline Gadus morhua (Atlantic cod) Animals Ingestion
Gly m 2 IUIS Glycine max (Soybean) Plants Inhalation
Gly m 50kD AllergenOnline Glycine max (Soybean) Plants Ingestion
Gly m 7 IUIS AllergenOnline Glycine max (Soybean) Plants Ingestion
Har a 1 IUIS Harmonia axyridis (Asian ladybeetle) Animals Inhalation
Hev b 5 IUIS AllergenOnline Hevea brasiliensis (Para rubber tree) Plants Contact
Hum j 1 IUIS AllergenOnline Humulus japonicus (Japanese hop) Plants Inhalation
Lac s 1 IUIS Lactuca sativa (Garden lettuce) Plants Ingestion
Len c 2 IUIS Lens culinaris (Lentil) Plants Ingestion
Lip b 1 IUIS Liposcelis bostrychophila (Booklouse) Animals Inhalation
Mala s 1 IUIS AllergenOnline Malassezia sympodialis (Skin colonizing yeast) Fungi Contact
Mala s 7 IUIS AllergenOnline Malassezia sympodialis (Skin colonizing yeast) Fungi Contact
Mala s 8 IUIS AllergenOnline Malassezia sympodialis (Skin colonizing yeast) Fungi Contact
Mala s 9 IUIS AllergenOnline Malassezia sympodialis (Skin colonizing yeast) Fungi Contact
Man e 5 IUIS AllergenOnline Manihot esculenta (Cassava) Plants Ingestion
Mus a 3 IUIS Musa acuminata (Banana) Plants Ingestion
Myr b pilosulin AllergenOnline Myrmecia banksi (Jack jumper ant) Animals Sting, bite
Myr p 1 IUIS AllergenOnline Myrmecia pilosula (Jack jumper ant) Animals Sting, bite
Myr p 2 IUIS AllergenOnline Myrmecia pilosula (Jack jumper ant) Animals Sting, bite
Myr p 3 IUIS Myrmecia pilosula (Jack jumper ant) Animals Sting, bite
Ole e 7 IUIS AllergenOnline Olea europaea (Olive) Plants Inhalation
Ory c 1 IUIS Oryctolagus cuniculus (Rabbit) Animals Inhalation
Par o 1 IUIS AllergenOnline Parietaria officinalis (Upright pellitory) Plants Inhalation
Par o 2F9-reactive AllergenOnline Parietaria officinalis (Upright pellitory) Plants Inhalation
Par o 8C7-reactive 1 AllergenOnline Parietaria officinalis (Upright pellitory) Plants Inhalation
Par o 8C7-reactive 2 AllergenOnline Parietaria officinalis (Upright pellitory) Plants Inhalation
Pen ch 33 IUIS Penicillium chrysogenum (Mold) Fungi Inhalation
Pru du conglutin gamma AllergenOnline Prunus dulcis (Almond) Plants Ingestion
Sec c 20 IUIS AllergenOnline Secale cereale (Rye) Plants Ingestion
Sec c 30 kDa AllergenOnline Secale cereale (Rye) Plants Inhalation
Sol g 2 IUIS Solenopsis geminata (Tropical fire ant) Animals Sting, bite
Sol g 4 IUIS AllergenOnline Solenopsis geminata (Tropical fire ant) Animals Sting, bite
Sol i 2 IUIS AllergenOnline Solenopsis invicta (Red imported fire ant) Animals Sting, bite
Sol i 4 IUIS AllergenOnline Solenopsis invicta (Red imported fire ant) Animals Sting, bite
Sol r 2 IUIS AllergenOnline Solenopsis richteri (Black imported fire ant) Animals Sting, bite
Sol s 2 IUIS Solenopsis saevissima (Brazilian fire ant) Animals Sting, bite
Sol s allergen 2 AllergenOnline Solenopsis saevissima (Brazilian fire ant) Animals Sting, bite
Sta c 3 IUIS AllergenOnline Stachybotrys chartarum (Toxic black mold) Fungi Inhalation
Tha p 2 IUIS AllergenOnline Thaumetopoea pityocampa (Pine processionary moth) Animals Contact
Thu a 2 IUIS AllergenOnline Thunnus albacares (Yellowfin tuna) Animals Ingestion
Tri a 19 IUIS AllergenOnline Triticum aestivum (Wheat) Plants Ingestion
Tri a 42 IUIS AllergenOnline Triticum aestivum (Wheat) Plants Ingestion; Inhalation
Tri a CC AllergenOnline Triticum aestivum (Wheat) Plants Inhalation
Tri t 1 IUIS Trichophyton tonsurans (Scalp ringworm fungus) Fungi Contact
Trip s 1 IUIS Triplochiton scleroxylon (African obeche tree) Plants Inhalation

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Clicking on the IUIS and AllergenOnline links leads you to the allergen descriptions in the IUIS Allergen Nomenclature Database and AllergenOnline.

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Grant, C.R.; Rees, T.A.

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Morton, N.; Dickerson, A.G.; Hammond, J.B.W.

Mannitol metabolism in Agaricus bisporus: Purification and properties of mannitol dehydrogenase

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Boutelje, J.; Hult, K.; Gatenbeck, S.

Mannitol dehydrogenase from industrial waste mycelium of Penicillium chrysogenum. Purification, properties and possible use in cofactor regenerating systems in vitro

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Purification and characterization of mannitol dehydrogenase from Aspergillus parasiticus

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Polyol dehydrogenases in the rust fungus, Melampsora lini (Ehrenb.) Lev.

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Purification and properties of mannitol dehydrogenase from Agaricus bisporus sporocarps

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Polyol metabolism in Diplodia viticola Desm.

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Mannitol dehydrogenase from Agaricus campestris

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Carbohydrate metabolism in Agaricus bisporus: Oxidative pathways in mycelium and sporophore

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The crystallographic structure of the mannitol 2-dehydrogenase NADP+ binary complicated from Agaricus bisporus

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Crystallization and preliminary crystallographic analysis of mannitol dehydrogenase (MtDH) from the common mushroom Agaricus bisporus

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Agaricus bisporus

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Purification and characterization of a novel mannitol dehydrogenase from a newly isolated strain of Candida magnoliae

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Controlling substrate concentration in fed-batch Candida magnoliae culture increases mannitol production

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Fusarium graminearum

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Alternaria alternata, Alternaria alternata (P0C0Y4)

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Cladosporium herbarum, Cladosporium herbarum (P0C0Y5)

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Tuber borchii (Q1ACW3), Tuber borchii

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between Malassezia and host cells in the pathogenesis of AD. Malassezia yeasts in canine atopic dermatitis Malassezia pachydermatis is the predominant organism amongst the skin mycobiota of dogs [56]; the lipid- dependent Malassezia spp.

associated with human diseases are only extremely rarely encountered [57\u]. An association between Malassezia dermatitis and CAD was recognized in one of the original case series describing M. pachydermatis as a skin pathogen in dogs; Mason and Evans diagnosed concurrent CAD in 2 out of 11 cases [60]. CAD tends to be the most frequently diagnosed concurrent disease in dogs with Malassezia dermatitis [61,62]. Studies of Malassezia colonization in dogs with CAD own consistently shown that, as a group, atopic dogs own higher skin populations of M. pachydermatis than healthy control dogs, particularly in the axilla, groin, interdigital skin, and beneath the tail [63,64].

More recently, Nardoni et al. [65] also showed that M. pachydermatis could be frequently isolated from the interdigital skin (71%) and ears (63%) in a group of 41 atopic dogs. Interestingly, a genetic subtype (3D) of M. pachydermatis, identified by sequencing of the intergenic spacer 1 (IGS-1) region of the ribosomal DNA, was found to be particularly prevalent in Japanese dogs with CAD [66]. Phospholipase activity from subtype 3D in vitro was higher when compared with subtypes isolated from healthy dogs [66]; phospholipase activity has recently been identified as a candidate virulence factor in M.

pachydermatis infection in dogs [67], in parallel with reports of the potential role of lipases in the pathogenesis of Malassezia-associated skin diseases in humans [68,69]. The increased colonization of canine atopic skin by M. pachydermatis is associated with strong serum IgG responses that are not protective [70\u]. The role of IgE and immediate hypersensitivity is of specific interest in atopic dogs, particularly in view of the dramatic clinical response of some severely affected atopic dogs to antifungal therapy [74], and its role in human AD. Immediate intradermal test reactivity to M.

pachydermatis allergens responses show that direct contact with the yeast induces skin inflammation; (3) sensitization occurs to an array of recombinant allergens; (4) AD patients own Th2 cells specific to Malassezia; and (5) antifungal treatment results in a clinical improvement [46,47]. Sensitization to M. sympodialis has also been demonstrated in a little number of human patients with the so-called \uintrinsic form\u of AD; these patients did not own elevated IgE titres to environmental or food allergens, but showed positive skin-prick or patch-test reactivity to Malassezia or peripheral blood mononuclear cell proliferative responses to crude or recombinant allergens [47].

The use of crude extracts of fungi such as Malassezia is potentially associated with difficulties relating to instability and variability, as previously discussed in relation to environmental moulds. The characterization and expression of Malassezia-derived recombinant proteins has led to recognition of sequence homology with human proteins; some of these host proteins own been shown to induce skin-prick test reactions and specific T-cell proliferation in patients sensitized to the corresponding fungal allergens, indicating that autoreactive skin-homing T cells might be relevant for cutaneous inflammation in patients with AD sensitized to Malassezia species based on molecular mimicry [48].

Mala s 11, a kDa allergen cloned from M. sympodialis, has sequence homology with manganese superoxide dismutase [49]. Superoxide dismutase enzymes exist in eukaryotic cells to neutralize toxic reactive oxygen species generated in mitochondria by the process of oxidative phosphorylation [50]. In pathogenic fungi, superoxide dismutase enzymes may act as a virulence factor by providing resistance against reactive oxygen species generated within phagocytic cells [50].

Evidence has been presented that suggests IgE-mediated sensitization to Malassezia-derived manganese superoxide dismutase in humans might lead to cross-reaction and autoimmunity to manganese superoxide dismutase derived from host cells [51]. Similar issues of cross reactivity own been proposed in relation to Mala s 6, a cyclophilin [52] and Mala s 13, a thioredoxin (Trx). Mala s 13 T-cell clones generated from peripheral blood and skin biopsy specimens of positive patch-test reactions in patients with AD sensitized to Mala s 13 and human Trx were fully cross reactive with human Trx [53].

Whilst the allergens of M. sympodialis own been investigated in detail, much less is known about the allergens of M. globosa. A 40\ukDa protein from M. globosa termed MG 42, shown to be highly reactive to IgE by western immunoblotting using sera from human AD patients, has been cloned and sequenced [54]. The sequence showed similarity to members of the heat shock protein 70 (hsp70) family, although no IgE cross- 62 Canine Allergy 6. Nolles G, Hoekstra MO, Schouten JP, et al.

Prevalence of immunoglobulin E for fungi in atopic children. Clinical and Experimental Allergy ; \u 7. Prester L. Indoor exposure to mould allergens. Arhiv Za Higijenu Rada i Toksikologiju ; \u 8. Chang FY, Lee JH, Yang YH, et al. Analysis of the serum levels of fungi-specific immunoglobulin E in patients with allergic diseases. International Archives of Allergy and Immunology ; 49\u 9. Hedayati MT, Arabzadehmoghadam A, Hajheydari Z.

Specific IgE against Alternaria alternata in atopic dermatitis and asthma patients. European Review for Medical and Pharmacological Sciences ; \u Montealegre F, Meyer B, Chardon D, et al. Comparative prevalence of sensitization to common animal, plant and mould allergens in subjects with asthma, or atopic dermatitis and/or allergic rhinitis living in a tropical environment. Clinical and Experimental Allergy ; 51\u Scalabrin DM, Bavbek S, Perzanowski MS, et al.

Use of specific IgE in assessing the relevance of fungal and dust mite allergens to atopic dermatitis: a comparison with asthmatic and nonasthmatic control subjects. Journal of Allergy and Clinical Immunology ; \u Cantani A, Ciaschi V. Epidemiology of Alternaria alternata allergy: a prospective study in Italian asthmatic children. European Review for Medical and Pharmacological Sciences ; 8: \u Reijula K, Leino M, Mussalo-Rauhamaa H, et al. IgE-mediated allergy to fungal allergens in Finland with special reference to Alternaria alternata and Cladosporium herbarum.

What is cladosporium herbarum allergy

Annals of Allergy, Asthma, and Immunology ; \u Crameri R, Weichel M, Fluckiger S, et al. Fungal allergies: a yet unsolved problem. Chemical Immunology and Allergy ; \u Vailes LD, Perzanowski MS, Wheatley LM, et al.

What is cladosporium herbarum allergy

IgE and IgG antibody responses to recombinant Alt a 1 as a marker of sensitization to Alternaria in asthma and atopic dermatitis. Clinical and Experimental Allergy ; \u Disch R, Menz G, Blaser K, et al. Diverse reactivity to recombinant Aspergillus fumigatus allergen I/a in patients with atopic dermatitis or allergic asthma sensitised to Aspergillus fumigatus. International Archives of Allergy and Immunology ; 89\u Hill PB, DeBoer DJ. The ACVD task force on canine atopic dermatitis (IV): environmental allergens. Veterinary Immunology and Immunopathology ; \u Scott DW. Observations on canine atopy. Journal of the American Animal Hospital Association ; 91\u Nesbitt GH, Kedan GS, Cacciolo P.

Canine atopy. 1. Etiology and diagnosis. Compendium of Continuing Education

Allergome Reference Archive
, Simon-Nobbe B
Title IgE-binding epitopes of enolases, a class of highly conserved fungal allergens
Authors Simon-Nobbe B, Probst G, Kajava AV, Oberkofler H, Susani M, Crameri R, Ferreira F, Ebner C, Breitenbach M
Journal J Allergy Clin Immunol ; (5)
Abstract BACKGROUND: Cladosporium herbarum and Alternaria alternata are two of the most prominent fungal species inducing type I allergy.

Previously, we own demonstrated that enolase (Cla h 6) is the second most significant allergen of C herbarum in terms of frequency of sensitization.

What is cladosporium herbarum allergy

OBJECTIVE: IgE-reactive B-cell epitopes of C herbarum enolase were analyzed, and cross-reactivity between fungal enolases was investigated. METHODS: Cla h 6 glutathione-S-transferase fusion peptides were constructed by means of PCR cloning. A alternata enolase (Alt a 5) was isolated by screening a complementary (c)DNA expression library with a C herbarum enolase DNA probe. RESULTS: Mapping of Cla h 6 IgE-binding epitopes identified a peptide with a length of 69 amino acids (peptide 9), which bound IgE from 8 of 8 patients.

Analysis of the conformation of peptide 9 revealed that it does not form a compact structure but rather spans the whole length of the protein, with side chains exposed to solvent at 3 locations. Peptide 9 in the contex t of Escherichia coli glutathione-S-transferase not only binds IgE but also competitively inhibits IgE binding to Alt a 5.

What is cladosporium herbarum allergy

This result indicates that the epitope or epitopes on peptide 9 constitute a major cross- reacting epitope or epitopes on the enolases from C herbarum and A alternata in the case of the one patient tested. CONCLUSIONS: We demonstrated that the glycolytic enzyme enolase is an allergen not only in C herbarum but also in A alternata.

What is cladosporium herbarum allergy

Additionally, enolase was shown to exhibit high cross-reactivity to other fungal enolases. On the basis of the results presented here, we propose the use of recombinant Cla h 6 or maybe even peptide 9 of Cla h 6 for diagnosis and possibly therapy of mold allergy

Language English
Address Institute of Genetics and General Biology, University of Salzburg, Salzburg; the Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg; Middle for Molecular Modeling, NIH-CIT, Bethesda; the Department of Laboratory Medicine, Landeskrankenanstalten Salzburg, Salzburg; Advanced Biological Systems Inc, Salzburg; Swiss Institute of Allergy and Asthma Research (SIAF), Davos; and the Department of Pathophysiology, University of Vienna, Vienna
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