What is alternaria allergy

<p>This section displays by default the canonical protein sequence and upon request every isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href=»»>length</a> and <a href=»»>molecular weight</a>. The information is filed in diverse subsections. The current subsections and their content are listed below:<p><a href=’/help/sequences_section’ target=’_top’>More</a></p>Sequencei

<p>This subsection of the <a href=»»>Sequence</a> section indicates if the <a href=»»>canonical sequence</a> displayed by default in the entry is finish or not.<p><a href=’/help/sequence_status’ target=’_top’>More</a></p>Sequence statusi: Complete.

Sequence databases

O [UniParc]FASTAAdd to basketAdded to basket« Hide 10 20 30 40 50
MHSSNNFFKD NIFRSLSKED PDYSRNIEGQ VIRLHWDWAQ LLMLSAKRMK
60 70 80 90
VAFKLDIEKD QRVWDRCTAD DLKGRNGFKR CLQFTLYRPR DLLSLLNEAF

FSAFRENRET IINTDLEYAA KSISMARLED LWKEYQKIFP SIQVITSAFR

SIEPELTVYT CLKKIEASFE LIEENGDPKI TSEIQLLKAS
Show »Last modified:May 1, — v1 <p>The checksum is a form of redundancy check that is calculated from the sequence.

It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two diverse sequences could own the same checksum worth, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence bit Cyclic Redundancy Check worth (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO standard. </p> <p class=»publication»>Press W.H., Flannery B.P., Teukolsky S.A.

and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href=»»>Numerical recipes in C 2nd ed., pp, Cambridge University Press ()</a>)</p> Checksum:i4AC72A

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href=’/help/cross_references_section’ target=’_top’>More</a></p>Cross-referencesi

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

MoreProtoNeti

Search

MobiDB: a database of protein disorder and mobility annotations

MoreMobiDBi

Search


<p>This section provides general information on the entry.<p><a href=’/help/entry_information_section’ target=’_top’>More</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier.

Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href=’/help/entry_name’ target=’_top’>More</a></p>Entry namei

ALTA2_ALTAL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href=’/help/accession_numbers’ target=’_top’>More</a></p>Accessioni OPrimary (citable) accession number: O
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the final sequence update and the date of the final annotation modification (‘Last modified’).

The version number for both the entry and the <a href=»»>canonical sequence</a> are also displayed.<p><a href=’/help/entry_history’ target=’_top’>More</a></p>Entry historyi

Integrated into UniProtKB/Swiss-Prot: July 22,
Last sequence update: May 1,
Last modified: December 11,
This is version 32 of the entry and version 1 of the sequence. See finish history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href=’/help/entry_status’ target=’_top’>More</a></p>Entry statusi Reviewed (UniProtKB/Swiss-Prot)
Annotation program Fungal Protein Annotation Program


<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href=’/help/miscellaneous_section’ target=’_top’>More</a></p>Miscellaneousi

Documents

  • Allergens
    Nomenclature of allergens and list of entries

@article{cff04bf3a01d7af37a09a,

title = «Evaluation of the prevalence of skin prick test positivity to Alternaria and Cladosporium in patients with suspected respiratory allergy.

A European multicenter study promoted by the subcommittee on Aerobiology and environmental aspects of inhalant allergens of the European Academy of allergology and clinical immunology»,

keywords = «Allergenic extract, Alternaria, Cladosporium, Mold allergy, Respiratory allergy, Skin prick test, Specific IgE determination»,

author = «G. D’Amato and G. Chatzigeorgiou and R. Corsico and D. Gioulekas and L. J{\»a}ger and S. J{\»a}ger and K. Kontou-Fili and S. Kouridakis and G. Liccardi and A. Meriggi and A. Palma-Carlos and Palma-Carlos, {M. L.} and {Pagan Aleman}, A.

and S. Parmiani and P. Puccinelli and M. Russo and Spieksma, {F. Th M} and R. Torricelli and B. W{\»u}thrich»,

year = «»,

language = «English»,

volume = «52»,

pages = «»,

journal = «Allergy: European Journal of Allergy and Clinical Immunology»,

issn = «»,

publisher = «Wiley-Blackwell»,

number = «7»,

}

M. Zureik, C. Neukirch, B. Leynaert, R. Liard, J. Bousquet et al., Sensitisation to airborne moulds and severity of asthma: cross sectional study from European Community respiratory health survey, BMJ, vol, issue, pp,
DOI : /bmj

Z.

Randriamanantany, I.

What is alternaria allergy

Annesi-maesano, D. Moreau, C. Raherison, D. Charpin et al., sensitization and allergic rhinitis with or without asthma in the French Six Cities study, Allergy, vol, issue.1 Suppl, pp,
DOI : /jx
URL :

M. Halonen, D. Stern, A. Wright, L. Taussig, and F. Martinez, Alternaria as a major allergen for asthma in children raised in a desert environment., American Journal of Respiratory and Critical Care Medicine, vol, issue.4, pp,
DOI : /ajrccm

P. Bousquet, S. Chinn, C. Janson, M. Kogevinas, P. Burney et al., Geographical variation in the prevalence of positive skin tests to environmental aeroallergens in the European Community Respiratory Health Survey I, Allergy, vol, issue.3, pp,
DOI : /jx

B.

Brunekreef, D. Dockery, F. Speizer, J. Ware, J. Spengler et al., Home Dampness and Respiratory Morbidity in Children, American Review of Respiratory Disease, vol, issue.5, pp,
DOI : /ajrccm/

J. Zock, D. Jarvis, C. Luczynska, J. Sunyer, and P. Burney, Housing characteristics, reported mold exposure, and asthma in the European Community Respiratory Health Survey, Journal of Allergy and Clinical Immunology, vol, issue.2, pp,
DOI : /mai

A. Verhoeff, R. Van-strien, J. Van-wijnen, and B. Brunekreef, Damp Housing and Childhood Respiratory Symptoms: The Role of Sensitization to Dust Mites and Molds, American Journal of Epidemiology, vol, issue.2, pp,
DOI : /a

P.

Salo, S. Arbes, . Jr, M. Sever, R. Jaramillo et al., Exposure to Alternaria alternata in US homes is??associated with asthma symptoms, Journal of Allergy and Clinical Immunology, vol, issue.4, pp,
DOI : /

C. Karihaloo, E. Tovey, T. Mitakakis, D. Duffy, and W.

What is alternaria allergy

Britton, Evidence for the genetic control of immunoglobulin E reactivity to the allergens of Alternaria alternata, Clinical <html_ent glyph=»@amp;» ascii=»&»/> Experimental Allergy, vol, issue.9, pp,
DOI : /s

R. Misiak, G. Wegienka, S. Havstad, D. Ownby, C. Johnson et al., Specific allergic sensitization in parents and their year-old offspring in the Suburban Detroit Childhood Allergy Study, Journal of Allergy and Clinical Immunology, vol, issue.6, pp,
DOI : /

T. Leung, N. Tang, C. Lam, A. Li, S. Fung et al., RANTES GA polymorphism is associated with allergen sensitization and FEV1 in Chinese children, Respiratory Medicine, vol, issue.2, pp,
DOI : /

L.

Weiss, L. Lester, J. Gern, R. Wolf, R. Parry et al., Is Associated with Asthma and Sensitization to Mold Allergen in Four Populations, American Journal of Respiratory and Critical Care Medicine, vol, issue.1, pp,
DOI : /rccmOC

J. Donfack, D. Schneider, Z. Tan, T. Kurz, I. Dubchak et al., Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy, Respiratory Research, vol, issue.2, p,
DOI : /

A.

Carvalho, A. Pasqualotto, L. Pitzurra, L. Romani, D. Denning et al., Polymorphisms in Toll???Like Receptor Genes and Susceptibility to Pulmonary Aspergillosis, The Journal of Infectious Diseases, vol, issue.4, pp,
DOI : /

A. Rogers, B. Raby, J. Lasky-su, A. Murphy, R. Lazarus et al., Assessing the Reproducibility of Asthma Candidate Gene Associations, Using Genome-wide Data, American Journal of Respiratory and Critical Care Medicine, vol, issue, pp,
DOI : /rccmOC

E. Thompson, L. Pan, I. Ostrovnaya, L. Weiss, J. Gern et al., Integrin ??3 genotype influences asthma and allergy phenotypes in the first 6 years of life, Journal of Allergy and Clinical Immunology, vol, issue.6, pp,
DOI : /

R.

Hynes, Integrins, Cell, vol, issue.6, pp,
DOI : /S(02)

A. Scaffidi, Y. Moodley, M. Weichselbaum, P. Thompson, and D. Knight, Regulation of human lung fibroblast phenotype and function by vitronectin and vitronectin integrins, J Cell Sci, vol, pp,

G. Gerold, K. Ajaj, M.

What is alternaria allergy

Bienert, H. Laws, A. Zychlinsky et al., A Toll-like receptor 2???integrin ??3 complicated senses bacterial lipopeptides via vitronectin, Nature Immunology, vol, issue.7, pp,
DOI : /ni

L. Smit, V. Siroux, E. Bouzigon, M. Oryszczyn, M. Lathrop et al., and Toll-like Receptor Gene Polymorphisms, Country Living, and Asthma in Adults, American Journal of Respiratory and Critical Care Medicine, vol, issue.5, pp,
DOI : /rccmOC
URL :

F. Kauffmann, M.

Dizier, I. Pin, E. Paty, F. Gormand et al., Epidemiological Study of the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy, American Journal of Respiratory and Critical Care Medicine, vol, issue.4, pp,
DOI : /ajrccmtac9
URL :

F. Kauffmann and M. Dizier, EGEA (Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy)-design issues, Clinical <html_ent glyph=»@amp;» ascii=»&»/> Experimental Allergy, vol.7, issue.6, pp,
DOI : /a0

V.

Siroux, A. Boudier, J. Bousquet, J.

What is alternaria allergy

Bresson, J. Cracowski et al., Phenotypic determinants of uncontrolled asthma, Journal of Allergy and Clinical Immunology, vol, issue.4, pp,
DOI : /
URL :

F. Kauffmann, M. Oryszczyn, and J. Maccario, The protective role of country living on skin prick tests, immunoglobulin E and asthma in adults from the Epidemiological study on the Genetics and Environment of Asthma, bronchial hyper-responsiveness and atopy, Clinical <html_ent glyph=»@amp;» ascii=»&»/> Experimental Allergy, vol, issue.3, pp,
DOI : /S(97)

Y.

Benjamini and Y. Hochberg, Controlling the untrue discovery rate: a practical and powerful approach to multiple testing, J R Statist Soc B, vol, pp,

O. Driscoll, B. Powell, G. Chew, F. Niven, R. Miles et al., Comparison of skin prick tests with specific serum immunoglobulin E in the diagnosis of fungal sensitization in patients with severe asthma, Clinical & Experimental Allergy, vol, issue, pp,
DOI : /jx

L. Weiss, C. Ober, E. Cook, and J. , ITGB3 shows genetic and expression interaction with SLC6A4, Human Genetics, vol, issue.1, pp,
DOI : /sz

A.

Undas, K. Brummel, J. Musial, K. Mann, and A. Szczeklik, PlA2 Polymorphism of ??3 Integrins Is Associated With Enhanced Thrombin Generation and Impaired Antithrombotic Action of Aspirin at the Site of Microvascular Injury, Circulation, vol, issue, pp,
DOI : /hc

J. Rossouw, M. Cushman, P. Greenland, L. , D. Bray et al., Inflammatory, Lipid, Thrombotic, and Genetic Markers of Coronary Heart Disease Risk in the Women’s Health Initiative Trials of Hormone Therapy, Archives of Internal Medicine, vol, issue, pp,
DOI : /archinte

S.

Bojesen, A. Tybjaerg-hansen, and B. Nordestgaard, Integrin ??3 Leu33Pro Homozygosity and Risk of Cancer, JNCI Journal of the National Cancer Institute, vol, issue, pp,
DOI : /jnci/djg

A. Coutinho, I. Sousa, M. Martins, C. Correia, T. Morgadinho et al., Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels, Human Genetics, vol, issue.2, pp,
DOI : /s

D. Ma, R. Rabionet, I. Konidari, J. Jaworski, H. Cukier et al., Association and gene-gene interaction of SLC6A4 and ITGB3 in autism, Am J Med Genet B Neuropsychiatr Genet, vol, pp,

K. Chen, W. Gu, L.

Zeng, D. Jiang, L. Zhang et al., Identification of Haplotype Tag SNPs Within the Entire TLR2 Gene and Their Clinical Relevance in Patients With Major Trauma, Shock, vol, issue.1, pp,
DOI : /SHK.0beeb45b3

C. Ober and D. Vercelli, Gene???environment interactions in human disease: nuisance or opportunity?, Trends in Genetics, vol, issue.3,
DOI : /

M. Ege, D. Strachan, W. Cookson, M. Moffatt, I. Gut et al., Gene-environment interaction for childhood asthma and exposure to farming in Central Europe, Journal of Allergy and Clinical Immunology, vol, issue.1, pp,
DOI : /

A.

What is alternaria allergy

Simpson and F. Martinez, The role of lipopolysaccharide in the development of atopy in humans, Clinical & Experimental Allergy, vol, issue.2, pp,
DOI : /jx

P. Salo, M. Yin, S. Arbes, . Jr, R. Cohn et al., Dustborne Alternaria alternata antigens in US homes: Results from the National Survey of Lead and Allergens in Housing, Journal of Allergy and Clinical Immunology, vol, issue.3, pp,
DOI : /

AF Heat shock protein Hsp70

Biochemical properties

Hsp70 proteins are ubiquitous chaperones that catalyze protein folding driven by hydrolysis of ATP [1].

Allergens from this family

Allergens belonging to the Hsp70 family are found in a heterogeneous range of sources. Several fungal allergens belong to this family such as Mala s 10 from Malassezia sympodialis [2] and Alt a 3 from Alternaria alternata. In addition, the hazel pollen allergen Cor a 10 [3] and Der f 28 from the mite Dermatophagoides farinae [4] belong to this family.

[top]

Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF Hsp70 protein CL Actin-like ATPase Superfamily

References

@article{cff04bf3a01d7af37a09a,

title = «Evaluation of the prevalence of skin prick test positivity to Alternaria and Cladosporium in patients with suspected respiratory allergy.

A European multicenter study promoted by the subcommittee on Aerobiology and environmental aspects of inhalant allergens of the European Academy of allergology and clinical immunology»,

keywords = «Allergenic extract, Alternaria, Cladosporium, Mold allergy, Respiratory allergy, Skin prick test, Specific IgE determination»,

author = «G. D’Amato and G. Chatzigeorgiou and R. Corsico and D. Gioulekas and L. J{\»a}ger and S. J{\»a}ger and K. Kontou-Fili and S. Kouridakis and G. Liccardi and A. Meriggi and A. Palma-Carlos and Palma-Carlos, {M. L.} and {Pagan Aleman}, A. and S. Parmiani and P.

Puccinelli and M. Russo and Spieksma, {F. Th M} and R. Torricelli and B. W{\»u}thrich»,

year = «»,

language = «English»,

volume = «52»,

pages = «»,

journal = «Allergy: European Journal of Allergy and Clinical Immunology»,

issn = «»,

publisher = «Wiley-Blackwell»,

number = «7»,

}

M. Zureik, C. Neukirch, B. Leynaert, R. Liard, J. Bousquet et al., Sensitisation to airborne moulds and severity of asthma: cross sectional study from European Community respiratory health survey, BMJ, vol, issue, pp,
DOI : /bmj

Z.

Randriamanantany, I. Annesi-maesano, D. Moreau, C. Raherison, D. Charpin et al., sensitization and allergic rhinitis with or without asthma in the French Six Cities study, Allergy, vol, issue.1 Suppl, pp,
DOI : /jx
URL :

M. Halonen, D. Stern, A. Wright, L. Taussig, and F. Martinez, Alternaria as a major allergen for asthma in children raised in a desert environment., American Journal of Respiratory and Critical Care Medicine, vol, issue.4, pp,
DOI : /ajrccm

P. Bousquet, S. Chinn, C. Janson, M. Kogevinas, P. Burney et al., Geographical variation in the prevalence of positive skin tests to environmental aeroallergens in the European Community Respiratory Health Survey I, Allergy, vol, issue.3, pp,
DOI : /jx

B.

Brunekreef, D. Dockery, F. Speizer, J. Ware, J. Spengler et al., Home Dampness and Respiratory Morbidity in Children, American Review of Respiratory Disease, vol, issue.5, pp,
DOI : /ajrccm/

J. Zock, D. Jarvis, C. Luczynska, J. Sunyer, and P. Burney, Housing characteristics, reported mold exposure, and asthma in the European Community Respiratory Health Survey, Journal of Allergy and Clinical Immunology, vol, issue.2, pp,
DOI : /mai

A.

Verhoeff, R. Van-strien, J. Van-wijnen, and B. Brunekreef, Damp Housing and Childhood Respiratory Symptoms: The Role of Sensitization to Dust Mites and Molds, American Journal of Epidemiology, vol, issue.2, pp,
DOI : /a

P. Salo, S. Arbes, . Jr, M. Sever, R. Jaramillo et al., Exposure to Alternaria alternata in US homes is??associated with asthma symptoms, Journal of Allergy and Clinical Immunology, vol, issue.4, pp,
DOI : /

C. Karihaloo, E. Tovey, T. Mitakakis, D. Duffy, and W.

Britton, Evidence for the genetic control of immunoglobulin E reactivity to the allergens of Alternaria alternata, Clinical <html_ent glyph=»@amp;» ascii=»&»/> Experimental Allergy, vol, issue.9, pp,
DOI : /s

R. Misiak, G.

What is alternaria allergy

Wegienka, S. Havstad, D. Ownby, C. Johnson et al., Specific allergic sensitization in parents and their year-old offspring in the Suburban Detroit Childhood Allergy Study, Journal of Allergy and Clinical Immunology, vol, issue.6, pp,
DOI : /

T. Leung, N. Tang, C. Lam, A. Li, S. Fung et al., RANTES GA polymorphism is associated with allergen sensitization and FEV1 in Chinese children, Respiratory Medicine, vol, issue.2, pp,
DOI : /

L. Weiss, L. Lester, J. Gern, R. Wolf, R. Parry et al., Is Associated with Asthma and Sensitization to Mold Allergen in Four Populations, American Journal of Respiratory and Critical Care Medicine, vol, issue.1, pp,
DOI : /rccmOC

J.

Donfack, D. Schneider, Z. Tan, T. Kurz, I.

What is alternaria allergy

Dubchak et al., Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy, Respiratory Research, vol, issue.2, p,
DOI : /

A. Carvalho, A. Pasqualotto, L. Pitzurra, L. Romani, D. Denning et al., Polymorphisms in Toll???Like Receptor Genes and Susceptibility to Pulmonary Aspergillosis, The Journal of Infectious Diseases, vol, issue.4, pp,
DOI : /

A. Rogers, B. Raby, J. Lasky-su, A. Murphy, R. Lazarus et al., Assessing the Reproducibility of Asthma Candidate Gene Associations, Using Genome-wide Data, American Journal of Respiratory and Critical Care Medicine, vol, issue, pp,
DOI : /rccmOC

E.

Thompson, L. Pan, I. Ostrovnaya, L. Weiss, J. Gern et al., Integrin ??3 genotype influences asthma and allergy phenotypes in the first 6 years of life, Journal of Allergy and Clinical Immunology, vol, issue.6, pp,
DOI : /

R. Hynes, Integrins, Cell, vol, issue.6, pp,
DOI : /S(02)

A. Scaffidi, Y. Moodley, M. Weichselbaum, P. Thompson, and D. Knight, Regulation of human lung fibroblast phenotype and function by vitronectin and vitronectin integrins, J Cell Sci, vol, pp,

G.

Gerold, K. Ajaj, M. Bienert, H. Laws, A. Zychlinsky et al., A Toll-like receptor 2???integrin ??3 complicated senses bacterial lipopeptides via vitronectin, Nature Immunology, vol, issue.7, pp,
DOI : /ni

L. Smit, V. Siroux, E. Bouzigon, M. Oryszczyn, M. Lathrop et al., and Toll-like Receptor Gene Polymorphisms, Country Living, and Asthma in Adults, American Journal of Respiratory and Critical Care Medicine, vol, issue.5, pp,
DOI : /rccmOC
URL :

F. Kauffmann, M. Dizier, I. Pin, E. Paty, F. Gormand et al., Epidemiological Study of the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy, American Journal of Respiratory and Critical Care Medicine, vol, issue.4, pp,
DOI : /ajrccmtac9
URL :

F.

Kauffmann and M. Dizier, EGEA (Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy)-design issues, Clinical <html_ent glyph=»@amp;» ascii=»&»/> Experimental Allergy, vol.7, issue.6, pp,
DOI : /a0

V. Siroux, A. Boudier, J. Bousquet, J. Bresson, J. Cracowski et al., Phenotypic determinants of uncontrolled asthma, Journal of Allergy and Clinical Immunology, vol, issue.4, pp,
DOI : /
URL :

F. Kauffmann, M. Oryszczyn, and J. Maccario, The protective role of country living on skin prick tests, immunoglobulin E and asthma in adults from the Epidemiological study on the Genetics and Environment of Asthma, bronchial hyper-responsiveness and atopy, Clinical <html_ent glyph=»@amp;» ascii=»&»/> Experimental Allergy, vol, issue.3, pp,
DOI : /S(97)

Y.

Benjamini and Y. Hochberg, Controlling the untrue discovery rate: a practical and powerful approach to multiple testing, J R Statist Soc B, vol, pp,

O. Driscoll, B. Powell, G. Chew, F. Niven, R. Miles et al., Comparison of skin prick tests with specific serum immunoglobulin E in the diagnosis of fungal sensitization in patients with severe asthma, Clinical & Experimental Allergy, vol, issue, pp,
DOI : /jx

L. Weiss, C. Ober, E. Cook, and J. , ITGB3 shows genetic and expression interaction with SLC6A4, Human Genetics, vol, issue.1, pp,
DOI : /sz

A.

Undas, K. Brummel, J. Musial, K. Mann, and A. Szczeklik, PlA2 Polymorphism of ??3 Integrins Is Associated With Enhanced Thrombin Generation and Impaired Antithrombotic Action of Aspirin at the Site of Microvascular Injury, Circulation, vol, issue, pp,
DOI : /hc

J. Rossouw, M. Cushman, P. Greenland, L. , D. Bray et al., Inflammatory, Lipid, Thrombotic, and Genetic Markers of Coronary Heart Disease Risk in the Women’s Health Initiative Trials of Hormone Therapy, Archives of Internal Medicine, vol, issue, pp,
DOI : /archinte

S. Bojesen, A. Tybjaerg-hansen, and B. Nordestgaard, Integrin ??3 Leu33Pro Homozygosity and Risk of Cancer, JNCI Journal of the National Cancer Institute, vol, issue, pp,
DOI : /jnci/djg

A.

Coutinho, I. Sousa, M. Martins, C. Correia, T. Morgadinho et al., Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels, Human Genetics, vol, issue.2, pp,
DOI : /s

D. Ma, R. Rabionet, I.

What is alternaria allergy

Konidari, J. Jaworski, H. Cukier et al., Association and gene-gene interaction of SLC6A4 and ITGB3 in autism, Am J Med Genet B Neuropsychiatr Genet, vol, pp,

K. Chen, W. Gu, L. Zeng, D. Jiang, L. Zhang et al., Identification of Haplotype Tag SNPs Within the Entire TLR2 Gene and Their Clinical Relevance in Patients With Major Trauma, Shock, vol, issue.1, pp,
DOI : /SHK.0beeb45b3

C. Ober and D. Vercelli, Gene???environment interactions in human disease: nuisance or opportunity?, Trends in Genetics, vol, issue.3,
DOI : /

M.

Ege, D. Strachan, W. Cookson, M. Moffatt, I. Gut et al., Gene-environment interaction for childhood asthma and exposure to farming in Central Europe, Journal of Allergy and Clinical Immunology, vol, issue.1, pp,
DOI : /

A. Simpson and F. Martinez, The role of lipopolysaccharide in the development of atopy in humans, Clinical & Experimental Allergy, vol, issue.2, pp,
DOI : /jx

P. Salo, M. Yin, S. Arbes, . Jr, R. Cohn et al., Dustborne Alternaria alternata antigens in US homes: Results from the National Survey of Lead and Allergens in Housing, Journal of Allergy and Clinical Immunology, vol, issue.3, pp,
DOI : /

AF Heat shock protein Hsp70

Biochemical properties

Hsp70 proteins are ubiquitous chaperones that catalyze protein folding driven by hydrolysis of ATP [1].

Allergens from this family

Allergens belonging to the Hsp70 family are found in a heterogeneous range of sources. Several fungal allergens belong to this family such as Mala s 10 from Malassezia sympodialis [2] and Alt a 3 from Alternaria alternata. In addition, the hazel pollen allergen Cor a 10 [3] and Der f 28 from the mite Dermatophagoides farinae [4] belong to this family.

[top]

Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF Hsp70 protein CL Actin-like ATPase Superfamily

References

  • Mayer MP, Bukau B:
    Hsp70 chaperones: cellular functions and molecular mechanism.
    Cell Mol Life Sci , 62, [PubMed][Full Text]
  • Andersson A, Rasool O, Schmidt M, Kodzius R, Fluckiger S, Zargari A, Crameri R, Scheynius A:
    Cloning, expression and characterization of two new IgE-binding proteins from the yeast Malassezia sympodialis with sequence similarities to heat shock proteins and manganese superoxide dismutase.
    Eur J Biochem , , [PubMed][Full Text]
  • Gruehn S, Suphioglu C, O’Hehir RE, Volkmann D:
    Molecular cloning and characterization of hazel pollen protein (70 kD) as a luminal binding protein (BiP): a novel cross-reactive plant allergen.
    Int Arch Allergy Immunol , , [PubMed][Full Text]
  • Aki T, Fujikawa A, Wada T, Jyo T, Shigeta S, Murooka Y, Oka S, Ono K:
    Cloning and expression of cDNA coding for a new allergen from the home dust mite, Dermatophagoides farinae: homology with human heat shock cognate proteins in the heat shock protein 70 family.
    J Biochem , , [PubMed]

[top]

Links to Wikipedia

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If you own updates or corrections for this entry, please contact the site istrator: christian.radauer@meduniwien.ac.at .

The long-term goal of this project is to better understand the immunologic mechanisms of asthma and allergic diseases. These diseases are generally thought to result from dysregulated immune responses to environmental proteins and organisms, which are mediated by Th2 cells. However, several fundamental questions still remain. How do patients develop such maladaptive T cell responses? Why don’t every patients who own detectable serum IgE antibodies (e.g. patients with allergic rhinoconjunctivitis) develop asthma? By using the Alternaria fungus, which has been implicated in human asthma, we own been studying how allergen-specific CD4+ T cells develop and which allergen molecules are critically involved.

We now hypothesize that the so-called Th2-type immune response to airborne allergens is mediated by two distinct CD4+ T cell subsets, namely Th2 cells and follicular T (Tfh) cells, which are critically involved in eosinophilic inflammation and gE antibody production, respectively. We also hypothesize that exogenous and endogenous ribonucleases (RNases) are involved in development of pathologic Th2 cells.
In Aim 1, we will use mouse models and determine the roles of Th2 cells and Tfh cells in Th2-type airway immune responses to Alternaria and other airborne allergens.

We will leverage cytokine reporter mice and gene-deficient mice and investigate the compartmentalized development of Th2 cells and Tfh cells.
In Aim 2, we will investigate the roles of Tfh cells in human airway disease. We will characterize blood CXCR5+CD4+ T cells, a human counterpart of Tfh cells, in a cohort of patients with short ragweed hay fever and examine the dynamic changes in these cells during the hay fever season.
In Aim 3, we will determine the roles of Alternaria-derived RNases and endogenous RNases, such as eosinophil-derived neurotoxin, in development and exacerbation of Th2 type immune responses.

We will integrate data obtained from in vitro experiments and in vivo mouse models. Recombinant Alternaria RNases and the fungi deficient in these RNases will be examined. The technical expertise required for these three Aims is readily available in the laboratories of Dr. Kita and his collaborator, Dr. Lawrence, a fungal functional genomics expert. The proposed studies are likely to provide a better understanding of the fundamental mechanisms underlying the development of Th2-type immunity to airborne allergens and will provide an explanation for the dissociation between robust airway inflammation and IgE antibody production in certain patients with allergic airway disorders.

The study will also likely identify potential key environmental and endogenous molecules that participate in the development of pathologic T cell responses in asthma. Ultimately, these studies will significantly enhance our understanding of the key cellular pathway(s) and molecule(s) involved in allergen- induced airway inflammation, allowing for identification of critical targets for development of novel therapeutic strategies to treat or to prevent asthma and related airway disorders.

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If you own updates or corrections for this entry, please contact the site istrator: christian.radauer@meduniwien.ac.at .

The long-term goal of this project is to better understand the immunologic mechanisms of asthma and allergic diseases. These diseases are generally thought to result from dysregulated immune responses to environmental proteins and organisms, which are mediated by Th2 cells. However, several fundamental questions still remain. How do patients develop such maladaptive T cell responses? Why don’t every patients who own detectable serum IgE antibodies (e.g.

patients with allergic rhinoconjunctivitis) develop asthma? By using the Alternaria fungus, which has been implicated in human asthma, we own been studying how allergen-specific CD4+ T cells develop and which allergen molecules are critically involved. We now hypothesize that the so-called Th2-type immune response to airborne allergens is mediated by two distinct CD4+ T cell subsets, namely Th2 cells and follicular T (Tfh) cells, which are critically involved in eosinophilic inflammation and gE antibody production, respectively. We also hypothesize that exogenous and endogenous ribonucleases (RNases) are involved in development of pathologic Th2 cells.
In Aim 1, we will use mouse models and determine the roles of Th2 cells and Tfh cells in Th2-type airway immune responses to Alternaria and other airborne allergens.

We will leverage cytokine reporter mice and gene-deficient mice and investigate the compartmentalized development of Th2 cells and Tfh cells.
In Aim 2, we will investigate the roles of Tfh cells in human airway disease. We will characterize blood CXCR5+CD4+ T cells, a human counterpart of Tfh cells, in a cohort of patients with short ragweed hay fever and examine the dynamic changes in these cells during the hay fever season.

In Aim 3, we will determine the roles of Alternaria-derived RNases and endogenous RNases, such as eosinophil-derived neurotoxin, in development and exacerbation of Th2 type immune responses. We will integrate data obtained from in vitro experiments and in vivo mouse models. Recombinant Alternaria RNases and the fungi deficient in these RNases will be examined. The technical expertise required for these three Aims is readily available in the laboratories of Dr. Kita and his collaborator, Dr. Lawrence, a fungal functional genomics expert.

The proposed studies are likely to provide a better understanding of the fundamental mechanisms underlying the development of Th2-type immunity to airborne allergens and will provide an explanation for the dissociation between robust airway inflammation and IgE antibody production in certain patients with allergic airway disorders. The study will also likely identify potential key environmental and endogenous molecules that participate in the development of pathologic T cell responses in asthma. Ultimately, these studies will significantly enhance our understanding of the key cellular pathway(s) and molecule(s) involved in allergen- induced airway inflammation, allowing for identification of critical targets for development of novel therapeutic strategies to treat or to prevent asthma and related airway disorders.


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