What is a ppd allergy

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Inbred Strains

Updated 9 Apr.
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

Abbott R. E. and Schachter D. () Inheritance of salt-dependent hypertension in the inbred Dahl rat. Hypertension24, \par

Abel E. L., Altman H. J., and Commissaris R. L. () Maudsley Reactive and Nonreactive rats in the forced swim test — comparison in fresh-water and soiled water. Physiol. Behav.52, \par

Adams M., Baverstock P. R., Watts C.

H. S., and Guttman G. A. () Enzyme markers in inbred rat strains: genetics of new markers and strain profiles. Biochem. Genet.22, \par

Adams N. and Blizard D. A. () Genetic and maternal influences in rat models of spontaneous and salt-induced hypertension. Developmental Psychobiology24, \par

Ajisawa C., Ikadai H., and Imamichi T. () Morphological study on the hypoplastic testis with aplasia of the epididymis, ductus deferens, and gland of the ductus deferens in the TW inbred rat.

Exp. Animals (Japan)34, \par

Alam M., Midtvedt T., and Uribe A. () Differential cell-kinetics in the ileum and colon of germ-free rats. Scandinavian Journal of Gastroenterology29, \par

Al-Dabbagh S. G., Idle J. R., and Smith R. L. () Animal modelling of human polymorphic drug oxidation- the metabolism of debrisoquine and phenacetin in rat inbred strains. J. Pharm. Pharmacol.33, \par

Allen E.

M. () The effect of iodine on lipid-peroxidation and ultrastructure in the thyroids of BB/Wor rats. Journal of Endocrinological Investigation15, \par

Ambrosio E., Goldberg S. R., and Elmer G. I. (a) Behavior genetic investigation of the relationship between spontaneous locomotor-activity and the acquisition of morphine self-istration behavior. Behavioural Pharmacology6, \par

Ambrosio E., Goldberg S. R., and Elmer G. I. (b) Behavior genetic investigation of the relationship between spontaneous locomotor-activity and the acquisition of morphine self- istration behavior. Behavioural Pharmacology6, \par

Amit Z.

and Smith B. R. () Differential ethanol intake in Tryon Maze-Bright and Tryon Maze-Dull rats — implications for the validity of the animal-model of selectively bred rats for high ethanol-consumption. Psychopharmacology, \par

Andersen A. E. () Phenylketonuria, supplement update to model no 47, in Handbook of animal models of human disease, fascicle 11 (Capen C. C., Hackel D. B., Jones T. C., and Migaki G., eds) Registry of Comparaitve pathology, Armed Forces Institute of Pathology, Washington, DC.\par

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Andolu J., Takahashi M., Imai S., Ishihara R., Kitamura T., Iijima T., Takano S., Nishiyama K., Suzuki K., and Maekawa A. () High-yield induction of uterine endometrial adenocarcinomas in DONRYU rats by a single intrauterine istration of n-ethyl-n’-nitro-n- nitrosoguanidine via the vagina.

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Armerding D., Katz D. H., and Benacerraf B. (b) Immune response genes in inbred rats. II. Segregation studies of the GT and GA genes and their linkage to the major histocompatibility complicated.

Immunogenet.1, \par

Armstrong J. M., Blackwell G. J., Flower R. J., McGiff J. C., Mullane K. M., and Vane J. R. () Genetic hypertension in rats is accompanied by a defect in renal prostaglandin catabolism. Nature, \par

Atkinson E. G., Edelsten C., Kasp E., and Dumonde D. C. () Experimental autoimmune uveoretinitis in the RCS rat — the influence of photoreceptor degeneration on disease expression. Brit.

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Aubry J. M., Bartanusz V., Driscoll P., Schulz P., Steimer T., and Kiss J. Z. () Corticotropin-releasing factor and vasopressin messenger-RNA levels in Roman High-Avoidance and Low-Avoidance rats — response to open- field exposure. Neuroendocrinology61, \par

Aulakh C. S., Hill J. L., and Murphy D. L. () Attenuation of hypercortisolemia in Fawn-Hooded rats by antidepressant drugs.

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Aulakh C. S., Hill J. L., and Murphy D. L. (a) Lithium treatment restores clonidines effect in an animal-model of depression. Pharmacol. Biochem. Behav.47, \par

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What is a ppd allergy

M., Hill J. L., and Murphy D. L. (b) Functional and biochemical-evidence for altered serotonergic function in the Fawn-Hooded rat strain. Pharmacol. Biochem. Behav.49, \par

Ayachi S () Increased dietary calcium lowers blood pressure in the spontaneously hypertensive rat. Metabolism28, \par

Azuma Y., Ito N., Shinohara M., and Mori M. () Experimental gingivitis in ODU plaque-susceptible rats. II. Biochemical nature of the rat plaque. J. Periodontol.49, \par

Azuma Y., Shinohara M., Ito N., and Mori M.

() Experimental gingivitis in ODU plaque-susceptible rats. III. Toxic activity of the rat dental plaque. J. Periodontol.50, \par

Badalamenti J., Shea M., Cybulsky A. V., Quigg R. J., and Salant D. J. () Heymann nephritis (HN) antigen in Lewis (LEW) and Brown Norway (BN) rats. Fed. Proc.46, \par

Badishtov B. A., Overstreet D. H., Kashevskaya O. P., Viglinskaya I. V., Kampovpolevoy A. B., Seredenin S.

B., and Halikas J. A. () To drink or not to drink — open-field behavior in alcohol-preferring and alcohol-nonpreferring rat strains. Physiol. Behav.57, \par

Bailey D. W. () Recombinant inbred strains, an aid to finding identity, linkage, and function of histocompatibility and other genes. Transplant.11, \par

Bakhle Y. S. and Bell C. () Increased numbers of substance P-containing sensory neurons in a rat strain with a genetic neurotrophic defect. Neuropeptides27, \par

Barber B.

R., Ferrari P., and Bianchi G. () The Milan hypertensive strain: a description of the model, in Handbook of Hypertension Vol. 16 Experimental and Genetic Models of Hypertension (Ganten D. and de Jong W., eds), pp. Elsevier, Amsterdam, New York, Oxford.\par

Barthold S. W., Moody K. D., Terwilliger G. A., Jacoby R. O., and Steere A. C. () An animal model for Lyme arthritis. Ann. NY Acad. Sci., \par

Bataillard A., Sacquet J., Julien C., Vincent M., Gomezsanchez C., Touraine J.

L., and Sassard J. () Do thymic-neuroendocrine interactions frolic a role in the antihypertensive effect of neonatal thymectomy in Lyon Hypertensive Rats. AJH6, \par

Baum A., Pohlmeyer G., Rapp K. G., and Deerberg F. () Lewis rats of the inbred strain LEW/Han — life expectancy, spectrum and incidence of spontaneous neoplasms. Experimental and Toxicologic Pathology47, \par

Bazin H. () Tumeurs secretant des immunoglobulines chez le rat LOU/Wsl. Etude portant sur immunocytomes. Ann. Immunol. (Paris)C, \par

Bazin H. () Inbred strains. Rat News Lett.1, \par

Bazin H.

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Bazin H., Beckers A., Deckers C., and Moriame M. () Transplantable immunoglobulin-secreting tumors in rats. V. Monoclonal immunoglobulins secreted by ileocecal immunocytomas in LOU/Wsl rats. J. Natl. Cancer Inst.51, \par

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Beckers A. and Bazin H. () Incidence of spontaneous ileocecal immunocytomas in hybrids of LOU/C rats and rat strains with low spontaneous tumor incidence: Brief communication.

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Beder K., Nagel M., Muller C. R., and Gunther E. () Electrophoretic protein variants in inbred strains of Rattus norvegicus: strain distribution, description of a new esterase polymorphism and linkage studies. Transplant. Proc.11, \par

Bell R. G. () Variation in responsiveness to Trichinella-spiralis infection in inbred rat strains.

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Belledonne M., Preuss J. M., and Preuss H. G. () Acid excretion in young and adult Wistar Kyoto and spontaneously hypertensive rats. Experientia35, \par

Bellhorn R. W., Rheinhardt J. M., Burns M. S., and Matthes M. T. () Retinal degeneration in the WKY rat. Degenerative Retinal Disorders: Clin. and Laboratory Invests. . Liss, Inc, Alan R.\par

Bender K., Ceve H., and Gunther E. () A previously described serum protein polymorphism in the rat identified as Gc (‘vitamin D-binding protein’).

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Bender K., Balogh P., Bertrand M. F., den Bieman M., von Deimling O., Eghtessadi S., Gutman G. A., Hedrich H. J., Hunt S. V., Kluge R., Matsumoto K., Moralejo D.

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Ben-Ishay B. () The Sabra hypertension-prone and -resistant strains, in Handbook of Hypertension Vol. 4. Experimental and genetic models of hypertension (de Jong W., ed), pp. Elsevier, Amsterdam, New York, Oxford.\par

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Berdanier C. D., Pan J. S., Hartle D. K., and Michaelis O. E. () Glucose-turnover in lean and obese rats of the SHE/N-cp and LA/N-cp strains. Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology, \par

Bertok L.

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Bianchi G., Fox U., and Imbasciati E. () Development of a new strain of spontaneously hypertensive rats. Life Sci.14, \par

Bianchi G., Ferrari P., and Barber B. R. () The Milan hypertensive strain, in Handbook of Hypertension Vol. 4. Experimental and genetic models of hypertension (de Jong W., ed), pp. Elsevier, Amsterdam, New York, Oxford.\par

Bianchi G., Tripodi G., Casari G., Salardi S., Barber B. R., Garcia R., Leoni P., Torielli L., Cusi D., Ferrandi M., Pinna L. A., Baralle F.

E., and Ferrari P. () 2 point mutations within the adducin genes are involved in blood- pressure variation. Proceedings of the National Academy of Sciences of the United States of America91, \par

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Billingham R. E. and Silvers W. K. () Inbred animals and tissue transplantation immunity. Transplant. Bull.6, \par

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Blizard D. A., Peterson W. N., and Adams N.

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Blottiere H. M., Menoret A., Burg C., Douillard J. Y., Meflah K., and Lependu J. (b) Characterization of an autoantigen (p) in a rat colon-carcinoma model.

Bulletin Du Cancer79, \par

Boorman G. A. and Hollander C. F. () Spontaneous lesions in the female WAG/Rij (Wistar) rat. J. Gerontol.28, \par

Boorman G. A. and Hollander C. F. () High incidence of spontaneous urinary bladder and ureter tumors in the brown Norway rat. J. Natl. Cancer Inst.52, \par

Boorman G. A., van Noord M. J., and Hollander C. F. () Naturally occurring medullary thyroid carcinoma in the rat.

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Boorman G. A., Zurcher C., Hollander C. F., and Feron V. J. () Naturally occurring endocardial disease in the rat. Arch. Pathol.96, \par

Boorman G. A., Eustis S. L., Elwell M. R., Montgomery J. C. A., and MacKenzie W. F. () Pathology of the Fischer rat. Academic Press, Inc, San Diego.\par

Borodin P. M. () Strains. Rat News Lett.1, \par

Bosland M. C., Prinsen M. K., Rivenson A., Silverman J., Fiala E., Williams G. M., Kroes R., and Weisburger J. H. (a) Induction of proliferative lesions of ventral prostate, seminal- vesicle, and other accessory sex glands in rats by N-methyl-N- nitrosourea — effect of castration, pretreatment with cyproterone- acetate and testosterone propionate, and rat strain.

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Bosland M. C., Prinsen M. K., Rivenson A., and Weisburger J. H. (b) Induction of skin and thyroid-tumors in male-rats by normal-methyl- normal-nitrosourea after sequential treatment with cyproterone- acetate and testosterone propionate — effects of castration, rat strain and time of carcinogen injection. Carcinogenesis13, \par

Braden A. W. H. () Strain differences in the incidence of polyspermia in rats after delayed mating. Fert. Steril.9, \par

Brdicka R. () Urinary proteins: interstrain differences in the laboratory rat.

Anim. Blood Gps. Biochem. Genet.15, \par

Breslin P. A. S., Spector A. C., and Grill H. J. () Sodium specificity of salt appetite in Fischer and Wistar rats is impaired by chorda tympani nerve transection. American Journal of Physiology-Regulatory Integrative and Comparative Physiology38, RR\par

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M., Provoost A. P., Daly M. J., Lander E. S., and Jacob H. J. () Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nature Genet.12, \par

Buchanan T. A., Fisler J. S., Underberger S., Sipos G. F., and Bray G. A. () Whole-body insulin sensitivity in Osborne-Mendel and S5B/Pl rats eating a low-fat or high-fat diet. Am. J. Physiol., RR\par

Buckley P., Hulse E. V., and Hold B. M.

() An inbred strain of rats with a high incidence of squamous-cell carcinomas of the mouth. Brit. J. Cancer41, \par

Buda M., Lachuer J., Devauges V., Barbagli B., Blizard D., and Sara S. J. () Central noradrenergic reactivity to stress in Maudsley rat strains. Neurosci. Let., \par

Burek J. D. () Pathology of aging rats. CRC Press, West Palm Beach, Florida.\par

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Burek J. D. and Hollander C. F. () Incidence patterns of spontaneous tumors in BN/Bi rats.

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Burek J. D., Zurcher C., and Hollander C. F. () Spontaneous cervical and vaginal tumors in the females BN/Bi rat, in Annual Report, Organization for Health Research, pp. TNO, Rijswijk.\par

Burek J. D., Zurcher C., and Hollander C. F. () High incidence of spontaneous cervical and vaginal tumors in an inbred strain of Brown Norway rats (BN/Bi). J. Natl. Cancer Inst.57, \par

Burnet P. W. J., Michelson D., Smith M. A., Gold P. W., and Sternberg E.

M. () The effect of chronic imipramine istration on the densities of 5-HT1a and 5-HT2 receptors and the abundancies of 5-HT receptor and transporter messenger-RNA in the cortex, hippocampus and dorsal raphe of 3 strains of rat. Brain Res., \par

Burtonboy G., Beckers A., Rodhain J., Bazin H., and Lamy M. E. () Rat ileocecal immunocytoma. An ultrastructural study with special attention to the presence of viral particles.

What is a ppd allergy

J. Natl. Cancer Inst.61, \par

Buttemeyer R., Rao U., and Jones N. F. () Peripheral-nerve allograft transplantation with FK — functional, histological, and immunological results before and after discontinuation of immunosuppression. Annals of Plastic Surgery35, \par

Byrnes A. P., Rusby J. E., Wood M. J. A., and Charlton H. M. () Adenovirus gene-transfer causes inflammation in the brain. Neuroscience66, \par

Calcagnetti D.

J. and Schechter M. D. () Deficits in shock-induced freezing and naltrexone enhancement of freezing in Fawn-Hooded rats. Brain Res. Bull.35, \par

Calderari S. A., Gonzalez A. C., and Gayol M. del C. () Spontaneous hypertriglyceridemic obesity and hyperglycemia in an inbred line of rats. Int. J. Obesity11, \par

Cameron T. P., Lattuada C. P., Kornreich M. R., and Tarone R. E. () Longevity and reproductive comparisons for male ACI and Sprague-Dawley rat aging colonies.

Lab. Animal Sci.32, \par

Cameron T. P., Hickman R. L., Kornreich M. R., and Tarone R. E. () History, survival, and growth patterns of B6C3F1 mice and F rats in the National Cancer Institute carcinogenesis testing program. Fundam. Appl. Toxicol.5, \par

Campbell D. J., Duncan A. M., Kladis A., and Harrap S. B. () Angiotensin peptides in spontaneously hypertensive and normotensive donryu rats. Hypertension25, \par

Carthew P., Wealthy K.

J., Martin E. A., De Matteis F., Lim C.-K., Manson M. M., Festing M. F. W., White I. N. H., and Smith L. L. () DNA damage as assessed by 32P-postlabelling in three rat strains exposed to dietary tamoxifen: the relationship between cell proliferation and liver tumour formation. Carcinogenesis16, \par

Castanon N. and Mormede P. () Psychobiogenetics — adapted tools for the study of the coupling between behavioral and neuroendocrine traits of emotional reactivity. Psychoneuroendocrinology19, \par

Castanon N., Dulluc J., Lemoal M., and Mormede P. () Prolactin as a link between behavioral and immune differences between the Roman rat lines.

Physiol. Behav.51, \par

Castanon N., Dulluc J., Lemoal M., and Mormede P. () Maturation of the behavioral and neuroendocrine differences between the Roman rat lines. Physiol. Behav.55, \par

Castanon N., Perezdiaz F., and Mormede P. () Genetic-analysis of the relationships between behavioral and neuroendocrine traits in Roman High-Avoidance and Low-Avoidance rat lines. Behav. Genet.25, \par

Ceccatelli S., Fahrenkrug J., Eneroth P., and Hokfelt T. () Vasoactive intestinal polypeptide peptide histidine isoleucine- immunoreactive neuron systems in the basal hypothalamus of a rat strain with deficient prolactin-release in response to stress.

Journal of Neuroendocrinology4, \par

Chang L. T., Kras K., Suzuki K., Strasburg G., Rodgers C. D., and Schemmel R. A. () Voluntary running in male S5B/Pl rats fed high-fat or high- carbohydrate diets. Physiol. Behav.57, \par

Chanh P. H., Kaiser R., Lassierre B., Navarro-Delmasure C., and Moutier R. () Creation of a strain of genetically obese-hypertensive rats. Int. J. Obesity12, \par

Chaouloff F., Castanon N., and Mormede P. () Paradoxical differences in animal-models of anxiety among the Roman rat lines.

Neurosci. Let., \par

Chappel C. I. and Chappel W. R. () The discovery and development of the BB rat colony: An animal model of spontaneous diabetes mellitus. Metabolism32, S8-S\par

Charnay Y., Steimer T., Huguenin C., and Driscoll P. () [H-3] paroxetine binding-sites — brain regional differences between 2 psychogenetically selected lines of rats. Neurosci. Res. Commun.16, \par

Chatterajee B., Demyan W.

F., Song C. S., Garg B. D., and Roy A. K. () Loss of androgenic induction of 2u-globulin gene family in the liver of NIH black rats. Endocrinol., \par

Chen X. H., Han J. S., and Huang L. T. () Cck receptor antagonist L, potentiated electroacupuncture analgesia in Wistar rats but not in audiogenic epileptic rats. Chinese Medical Journal, \par

Chisholm P. M., Smith M. E., Sparshott S. M., and Ford W. L. () A comparison of immune responses against Ag-B and non Ag-B antigens, presented alone or together. Transplant.23, \par

Chowdhury N. R., Gross F., Moscioni A. D., Kram M., Arias I.

M., and Chowdhury J. R. () Isolation of multiple normal and functionally faulty forms of uridine diphosphate-glucoronyltransferase from inbred Gunn rats. J. Clin. Invest.79, \par

Cicila G. T., Rapp J. P., Bloch K. D., Kurtz T. W., Pravenec M., Kren V., Hong C. C., Quertermous T., and Ng S. C. () Cosegregation of the endothelin-3 locus with blood-pressure and relative heart-weight in inbred Dahl rats. J. Hypertens.12, \par

Clark C. J., Milligan G., and Connell J. M. C. () Guanine-nucleotide regulatory protein alterations in the Milan Hypertensive rat strain.

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Clark C. J., Milligan G., and Connell J. M. C. () Guanine-nucleotide regulatory protein alterations in young Milan Hypertensive strain rats. Biochimica Et Biophysica Acta-Molecular Basis of Disease, \par

Clark R. L., Cuttino J. T., Anderle S. R., Cromartie W. J., and Schwab J. H. () Radiologic analysis of arthritis in rats after systemic injection of streptococcal cell walls. Arthritis Rheum.22, \par

Cockrell B. Y. and Garner F. M. () Interstitial cell tumor.

Comp. Pathol. Bull.8, \par

Coenen A. M. L. and Van Luijtelaar E. L. J. M. () The WAG/Rig rat model for absence epilepsy: age and sex factors. Epilepsy Res.1, \par

Coenen A. M. L., Drinkenberg W. H. I. M., Inoue M., and Van Luijtelaar E. L. J. M. () Genetic models of absence epilepsy, with emphasis on the WAG/Rij strain of rats. Epilepsy Res.12, \par

Cohen A. J., McCarthy D. M., and Rossetti R. R. () Renin secretion by the spontaneously diabetic rat. Diabetes35, \par

Cohen A.

M., Rosenmann E., and Rosenthal T. () The Cohen diabetic (non-insulin-dependent) hypertensive rat model. Description of the model and pathological findings. AJH6, \par

Cohen B. J., De Bruin R. W., and Kort W. J. () Heritable hydronephrosis in a mutant strain of brown Norway rats. Lab. Anim. Care20, \par

Cohen S. B. and Weetman A. P. () The effect of iodine depletion and supplementation in the Buffalo strain rat. J. Endocrinol. Invest.11, \par

Cohen S.

M. and Friedell G. H. () Carcinoma of the urinary bladder. Am. J. Pathol.95, \par

Coleman G. L., Barthold S. W., Osbaldistan G. W., Foster S. J., and Jonas A. M. () Pathological changes during aging in barrier-reared Fischer male rats. J. Gerontol.32, \par

Colly L. P. and Hagenbeek T. () Experimental chemotherapy: A rat model for human acute myeloid leukemia, in Experimental hematology today (Baum S. J. and Ledney D. G., eds), pp. Springer Verlag, New York.\par

Colombo G., Hansen C., Hoffman P. L., and Grant K. A. () Decreased performance in a delayed alternation task by rats genetically deficient in vasopressin.

Physiol. Behav.52, \par

Commissaris R. L., Harrington G. M., Baginski T. J., and Altman H. J. () MR/Har and MNRA/Har Maudsley rat strains: differences in acoustic startle habituation. Behav. Genet.18, \par

Commissaris R. L., Franklin L., Verbanac J. S., and Altman H. J. () Maudsley Reactive (MR/Har) and nonreactive (MNRA/Har) rats — performance in an operant conflict paradigm. Physiol. Behav.52, \par

Committee on the Care and Use of Spontaneously Hypertensive (SHR) Rats () Spontaneously hypertensive (SHR) rats: guidelines for breeding, care nd use.

ILAR News19, G1-G\par

Cowen L. A., Harold M. R., Chen C. M., Abbott R. E., and Schachter D. () Immunoglobulin and renal abnormalities in Dahl genetically hypertensive rat. Am. J. Physiol., HH\par

Cramer D. V. and Gill T. J. III () Genetics of urogenital abnormalities in ACI inbred rats. Teratology12, \par

Cramer D. V., Shonnard J. W., Davis B. K., and Gill III T. J. () Polymorphism of the mixed lymphocyte response of wild Norway rats. Transplant. Proc.9, \par

Cremer M. A., Terato K., Watson W. C., Griffiths M. M., Townes A. S., and Kang A. H. () Collagen-induced arthritis in rats — examination of the epitope specificities of circulating and cartilage-bound antibodies produced by outbred and inbred rats using cyanogen bromide-derived peptides purified from heterologous and homologous type-II collagens.

J. Immunol., \par

Cromartie W. J., Craddock J. C., Schwab J. H., Anderle S. K., and Yang C. H. () Arthritis in rats after systemic injection of streptococcal cells or cell walls. J. Exp. Med., \par

Cutler L. S., Bullis D., and Greiner D. L. () Experimental autoallergic sialadenitis in the LEW rat: A reproducible animal model of Sjogren’s syndrome. Transplant. Proc.19, \par

Czerwinski M. J. and Crowell J. S. Jr. () Genetic monitoring of the rat (Ratus norvegicus). Rat News Lett.17, \par

Dahl L. K., Heine M., and Tassinari L.

(a) Effects of chronic excess salt ingestion. Evidence that genetic factors frolic an significant role in susceptibility to experimental hypertension. J. Exp. Med., \par

Dahl L. K., Heine M., and Tassinari L. (b) Role of genetic factors in susceptibility to experimental hypertension due to chronic excess salt ingestion. Nature, \par

Dailey J. W., Reigel C. E., Mishra P. K., and Jobe P. C. () Review article. Neurobiology of seizure predisposition in the genetically epilepsy-prone rat.

Epilepsy Res.3, \par

Danis R. P. and Yang Y. H. () Microvascular retinopathy in the Zucker diabetic fatty rat. Investigative Ophthalmology & Visual Science34, \par

Davey F. R. and Moloney W. C. () Postmortem observations of Fischer rats with leukemia and other disorders. Lab. Invest.23, \par

Davis C. T., Blankenhorn E. P., and Murasko D. M. () Genetic variaion in the ability of several strains of rats to produce interferon in response to polyriboinosinic-polyribocytodilic acid.

What is a ppd allergy

Infect. Immun.43, \par

Deerberg F., Rehm S., and Jostmeyer H. H. () Spontaneous urinary bladder tumors in DA/Han rats: A feasible model of human bladder cancer. J. Natl. Cancer Inst.75, \par

Deerberg F., Pohlmeyer G., Lorcher K., and Petrow V. () Entire suppression of spontaneous endometrial carcinoma in BDII/Han rats by melengestrol acetate. Oncology52, \par

De Jong W., ed () Handbook of Hypertension, Vol. 4 Experimental and genetic models of hypertension. Elsevier, Amsterdam, New York, Oxford.\par

Dekozak Y., Naud M.

C., Bellot J., Faure J. P., and Hicks D. () Differential tumor-necrosis-factor expression by resident retinal cells from experimental uveitis-susceptible and uveitis-resistant rat strains. J. Neuroimmunol.55, \par

Dent J. G., Graichen M. E., Schnell S., and Lasker J. () Constitutive and induced hepatic microsomal cytochrome P monooxygenase activities in male Fischer rats and CD rats. A comparative study. Toxicol. Appl. Pharmacol.52, \par

Dhabhar F. S., McEwen B. S., and Spencer R. L. () Stress-response, adrenal-steroid receptor levels and corticosteroid- binding globulin levels — a comparison between Sprague-Dawley, Fischer and Lewis rats.

Brain Res., \par

Dietz R., Shomig A., and Rascher W. () Pathophysiological aspects of genetically-determined hypertension in rats with special emphasis on stroke prone spontaneously hypertensive rats, in Handbook of Hypertension Vol. 4. Experimental and genetic models of hypertension (de Jong W., ed), pp. Elsevier, Amsterdam, New York, Oxford.\par

Diloreto D., Cox C., Grover D. A., Lazar E., Delcerro C., and Delcerro M. () The influences of age, retinal topography, and gender on retinal degeneration in the Fischer rat.

Brain Res., \par

Dodds W. J. () Third international registry of animal models of thrombosis and hemorrhagic diseases. ILAR News30, R1-RR.\par

Donner M. E., Skow L. C., Kunz H. W., and Gill III T. J. () Electrophoretic variation in low molecular weight lens crystallins from inbred strains of rats. Biochem. Genet.23, \par

Douglas T. C., Kimmel C.

B., and Dawson P. E. () Genetically controlled variation of «acid» beta-galactosidase detected in Rattus norvegicus by isoelectric focussing. Genetics, \par

Dowling J. E. and Sidman R. L. () Inherited retinal dystrophy in the rat. J. Cell Biol.14, \par

Drinkenberg W. H. I. M., Coenen A. M. L., Vossen J. M. H., and Van Luijtelaar E. L. J.

What is a ppd allergy

M. () Spike-wave discharges and sleep-wake states in rats with absence epilepsy. Epilepsy Res.9, \par

Driscoll B. F., Kies M. W., and Alvord J. E. C. () The nature of the defect in experimental allergic encaphalomyelitis (EAE)-resistant Lewis (Le-R) rats. J. Immunol., \par

Driscoll P., Fumm H., and Battig K. () Maternal behavior in two rat lines selected for differences in the acquisition of two-way avoidance. Experientia35, \par

Druckrey H.

() Genotypes and phenotypes of ten inbred strains of BD-rats. Arzneim-Forsch. (Drug Research)21, \par

Druckrey H., Landschutz C., and Ivankovic S. () Transplacentare Erzeugnung maligner Tumoren des Nervensystems. II. Athyl-nitrosoharnstoff an 10 genetisch definierten Ratten-stammen. Z. Krebsforsch.73, \par

Dubay C., Vincent M., Samani N. J., Hilbert P., Kaiser M. A., Beressi J. P., Kotelevtsev Y., Beckmann J. S., Soubrier F., Sassard J., and Lathrop G. M. () Genetic-determinants of diastolic and pulse pressure map to diverse loci in Lyon Hypertensive Rats.

Nature Genet.3, \par

Dunning W. F. and Curtis M. R. () The respective roles of longevity and genetic specificity in the occurrence of spontaneous tumors in the hybrids between two inbred lines of rats. Cancer Res.6, \par

Dunning W. F., Curtis M. R., and Segaloff A. () Strain differences in response to diethylstilbestrol and the induction of mammary gland and bladder cancer in the rat. Cancer Res.7, \par

Dutsch H. R. and Battig H. () Psychogenetische unterschiede (RHA-vs RLA-Ratten) im vermeidungslernen, offenfeldverhalten, Hebb-Willisms-intelligenztest und be der labrinthexploration.

Z. Exp. Angew. Psychol.24, \par

Ebner S. A., Lueprasitsakul W., Alex S., Fang S. L., Appel M. C., and Braverman L. E. () Iodine content of rat thyroglobulin affects its antigenicity in inducing lymphocytic thyroiditis in the BB/Wor rat. Autoimmunity13, \par

Eisenberger U., Fels L. M., Olbricht C. J., and Stolte H. () Cathepsin-B and cathepsin-L in isolated proximal tubular segments during acute and chronic proteinuria.

Renal Physiology and Biochemistry18, \par

Elhifnawi E. () Localization of cathepsin-D in rat ocular-tissues — an immunohistochemical study. Annals of Anatomy-Anatomischer Anzeiger, \par

Elhifnawi E. S., Kuhnel W., Orun C., Haug H., and Laqua H. () The effect of cyclooxygenase inhibitors on the course of hereditary retinal dystrophy in RCS-rats. Annals of Anatomy-Anatomischer Anzeiger, \par

Elhifnawi E., Kuhnel W., Elhifnawi A., and Laqua H. () Localization of lysosomal-enzymes in the retina and retinal-pigment epithelium of RCS rats.

Annals of Anatomy-Anatomischer Anzeiger, \par

Ely D. L., Daneshvar H., Turner M. E., Johnson M. L., and Salisbury R. L. () The hypertensive Y-chromosome elevates blood-pressure in F11 normotensive rats. Hypertension21, \par

Ely J. M., Greiner D. L., Lubaroff D. M., and Fitch F. W. () Characterization of monoclonal antibodies that define rat T cell alloantigens. J. Immunol., \par

English J. C., Perry L. G., Vlaovic M., Moyer C., and Odonoghue J. L. () Measurement of cell-proliferation in the kidneys of Fischer and Sprague-Dawley rats after gavage istration of hydroquinone.

Fundam. Appl. Toxicol.23, \par

Esber H. J., Menninger F. F. Jr., and Bogden A. E. () Variation in serum hormone concentrations in diverse rat strains. Proc. Soc. Exp. Biol. Med., \par

Escorihuela R. M., Tobena A., Driscoll P., and Fernandezteruel A. () Effects of training, early handling, and perinatal flumazenil on shuttle box acquisition in Roman Low-Avoidance rats — toward overcoming a genetic deficit. Neuroscience and Biobehavioral Reviews19, \par

Essner E. and Gorrin G. () An electron microscopic study of macrophages in rats with inherited retinal dystrophy.

Invest. Ophthalmol. Visual Sci.18, \par

Essner E., Gorrin G., and Griewski R. A. () Localization of lysosomal enzymes in retinal pigment epithelium of rats with inherited retinal dystrophy. Invest. Ophthalmol. Visual Sci.17, \par

Essner E., Pino R. M., and Griewski R. A. () Permeability of retinal capillaries in rats with inherited retinal degeneration. Invest. Ophthalmol. Visual Sci.18, \par

Estape E.

S., Rodriguezsargent C., Cangiano J. L., and Candia O. A. () Increased dietary NaCl intake influences lens transport-properties in Sprague-Dawley rats. Current Eye Research14, \par

Ewel C. H., Sobel D. O., Zeligs B. J., and Bellanti J. A. () Poly-I-C accelerates development of diabetes-mellitus in diabetes-prone BB rat. Diabetes41, \par

Faktorovich E.

G., Steinberg R. H., Yasumura D., Matthes M. T., and Lavail M. M. () Basic fibroblast growth-factor and local injury protect photoreceptors from light damage in the rat. Journal of Neuroscience12, \par

Fan X. M., Hendley E. D., and Forehand C. J. () Enhanced vascular neuropeptideYy-immunoreactive innervation in 2 hypertensive rat strains. Hypertension26, \par

Fechtali T., Rostain J. C., and Abraini J. H. () Relationship between emotional status and spontaneous behavior in rats exposed to high-pressure.

Physiol. Behav.54, \par

Fernandezteruel A., Escorihuela R. M., Driscoll P., Tobena A., and Battig K. (a) Differential-effects of early stimulation and or perinatal flumazenil treatment in young Roman Low-Avoidance and High-Avoidance rats. Psychopharmacology, \par

Fernandezteruel A., Escorihuela R. M., Nunez J. F., Goma M., Driscoll P., and Tobena A. (b) Early stimulation effects on novelty-induced behavior in 2 psychogenetically-selected rat lines with divergent emotionality profiles.

Neurosci. Let., \par

Fernandezteruel A., Driscoll P., Escorihuela R. M., Tobena A., and Battig K. () Postnatal handling, perinatal flumazenil, and adult behavior of the Roman rat lines. Pharmacol. Biochem. Behav.44, \par

Fernandezteruel A., Escorihuela R. M., Driscoll P., Tobena A., and Battig K. () Evaluating activity and emotional reactivity in a hexagonal tunnel maze — correlational and factorial analysis from a study with the Roman-Verh rat lines.

Behav. Genet.24, \par

Ferrandi M., Minotti E., Salardi S., Florio M., Bianchi G., and Ferrari P. () Ouabain-like factor in Milan Hypertensive rats. Am. J. Physiol., FF\par

Ferrandi M., Minotti E., Salardi S., Florio M., Bianchi G., and Ferrari P. () Characteristics of a ouabain-like factor from Milan Hypertensive rats. J. Cardiovasc. Pharmacol.22, SS\par

Festing M. F. W. (a) Inbred strains, in The Laboratory Rat Vol. I. Biology and Diseases (Baker H. J., Lindsey J. R., and Weisbroth S. H., eds), pp. Academic Press, New York.\par

Festing M.

F. W. (b) Inbred strains in biomedical research, 1st ed. Macmillan Press, London, Basingstoke.\par

Festing M. F. W. Inbred strains of rats. Unpublished listing.\par

Festing M. F. W. and Bender K. () Genetic relationships between inbred strains of rats. An analysis based on genetic markers at 28 biochemical loci. Genet. Res.44, \par

Festing M.

F. W. and Blackmore D. K. () Life span of specified-pathogen-free (MRC category 4) mice and rats. Lab. Anim.5, \par

Festing M. F. W. and Staats J. () Standardized nomenclature for inbred strains of rats. Fourth listing. Transplant.16, \par

Festing M. F. W., Hawkey C. M., Hart M. G., Turton J. A., Gwynne J., and Hicks R. M. () Principal components analysis of haematological data from F rats with bladder cancer fed the retinoid N-(ethyl) -all-trans-retinamide. Food Chem. Toxicol22, \par

Foulkes R., Ferrario R.

G., Salvati P., and Bianchi G. () Differences in ouabain-induced natriuresis between isolated kidneys of Milan Hypertensive and Normotensive rats. Clin. Sci.82, \par

Fraser A. G., Debnam E. S., Dhillon A. P., and Pounder R. E. () Gastric epithelial-cell proliferation and histological damage after hypertonic sodium-chloride — the effect of variation in the strain of rat. International Journal of Experimental Pathology73, \par

Fregly M. J. () Thyroid activity of spontaneous hypertensive rats. Proc. Soc.

Exp. Biol. Med., \par

Friedman I., Ron N., Laufer A., and Davies A. M. () Experimental myocarditis: enhancement by the use of pertussis vaccine in Lewis rats. Experientia26, \par

Fujita O. () «Tsukuba Emotionality»; new selected strains. Rat News Lett.13, \par

Fumm H. and Battig H. () Development of exploratory behavior in RHA- and RLA-rats. Experientia35, \par

Funakoshi A., Miyasaka K., Shinozaki H., Masuda M., Kawanami T., Takata Y., and Kono A. () An animal-model of congenital defect of gene-expression of cholecystokinin (CCK)-a receptor.

Biochemical and Biophysical Research Communications, \par

Gahnem F., Vonlutterotti N., Camargo M. J. F., Laragh J. H., and Sealey J. E. () Angiotensinogen dependency of blood-pressure in 2 high-renin hypertensive rat models. AJH7, \par

Gao J., Sherman W. M., McCune S. A., and Osei K. () Effects of acute running exercise on whole-body insulin action in obese male SHHF/Mcc-fa(cp) rats. J.

What is a ppd allergy

Appl. Physiol.77, \par

Gasser D. L., Palm J., and Gonatas N. K. () Genetic control of susceptibility to experimental allergic encephalomyelitis and the Ag-B locus of rats. J. Immunol., \par

Gasser D. L., Balyannis S. J., and Gonatas N. K. () Influence of MHC-linked and non-MHC-linked genes on susceptibility of rats to experimental allergic encephalomyelitis, in Genetic control of autoimmune disease (Rose N. R., Bigazzi P. E., and Warner N. L., eds), pp. Elsevier-North Holland, New York.\par

Gasser D. L., Hickey W. F., and Gonatas N. K. () The genes for nonsusceptibility to EAE in the Le-R and BH strains are not linked to RT1.

Immunogenet.17, \par

Ghosh P., Somanchi M., and Lakshman M. R. () Regulatory enzymes of lipid-metabolism in LA/N-cp rats. Journal of Nutritional Biochemistry6, \par

Gilad G. M., Li R., Wyatt R. J., and Tizabi Y. () Effects of genotype on age-related alterations in the concentrations of stress hormones in plasma and hypothalamic monoamines in rats. J. Reprod. Fertil.S46, \par

Ginn D. I., Baptista C.

A. C., Alam K. Y., Deng A. Y., Cicila G. T., Margolius H. S., and Rapp J. P. () Estimate of the genetic-divergence between inbred Dahl salt-sensitive and salt-resistant rats. J. Hypertens.11, \par

Giorgi O., Orlandi M., Escorihuela R. M., Driscoll P., Lecca D., and Corda M. G. () Gabaergic and dopaminergic transmission in the brain of Roman High- Avoidance and Roman Low-Avoidance rats. Brain Res., \par

Gleiser C. A. and Shain S. A. () The aging AXC/SSh rat: assessment of longevity and prevalence of neoplastic and nonneoplastic diseases in necropsied rats.

J. Gerontol.41, \par

Glover E. L., Reuber M. D., and Godfrey F. () Methylcholanthrene-induced thyroiditis. Susceptibility of Buffalo strain rats. Arch. Environ. Health18, \par

Glowa J. R., Geyer M. A., Gold P. W., and Sternberg E. M. () Differential startle amplitude and corticosterone response in rats. Neuroendocrinology56, \par

Glowa J. R., Shaw A. E., and Riley A. L. () Cocaine-induced conditioned taste-aversions — comparisons between effects in LEW/N and F/N rat strains. Psychopharmacology, \par

Gold G.

and Widnell C. C. () Response of NADPH cytochrome c reductase and cytochrome P in hepatic microsomes to treatment with phenobarbital—Differences in rat strains. Biochem. Pharmacol.24, \par

Golden G. T., Smith G. G., Ferraro T. N., and Reyes P. F. () Rat strain and age-differences in kainic acid-induced seizures. Epilepsy Res.20, \par

Goldmuntz E. A., Wilder R. L., Goldfarb Y., Cash J. M., Zha H.

B., Crofford L. J., Mathern P., Hansen C. T., and Remmers E. F. () The origin of the autoimmune disease-resistant LER rat — an outcross between the Buffalo and autoimmune disease-prone Lewis inbred rat strains. J. Neuroimmunol.44, \par

Goldstein D. J., Wheeler D. C., Sandstrom D. J., Kawachi H., and Salant D. J. () Fish-oil ameliorates renal injury and hyperlipidemia in the Milan Normotensive rat model of focal glomerulosclerosis. Journal of the American Society of Nephrology6, \par

Gollner D., Kawachi H., Oite T., Oka M., Nagase M., and Shimizu F.

() Strain variation in susceptibility to the development of monoclonal- antibody induced proteinuria in rats. Clin. Exp. Immunol., \par

Gonzales F. J., Matsunuga T., Nagata K., Meyer U. A., Nebert D. W., Pastewka J., Kozak C. A., Gillette J., Gelboin H. V., and Hardwick J. P. () Debrisoquine 4-hydroxylase: characterization of a new P gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism. DNA6, \par

Goodall C. M. and Doesburg R.

M. N. () Age-specific incidence of neoplasms in untreated N2R/Gd rats: An inbred strain with cardiovascular tumours and liver glycogen storage disease. J. Pathol., \par

Goodall C. M., Christie G. S., and Hurley J. V. () Primary epithelial tumour in the correct atrium of the heart and inferior vena cava in NZR/Gd inbred rats; pathology of 18 cases. J. Pathol., \par

Goodman D. C., Ward J. M., Squire R. A., Chu K. C., and Linhart M. S. () Neoplastic and nonneoplastic lesions in aging F rats. Toxicol. Appl. Pharmacol.48, \par

Gordon C. J. and Watkinson W.

P. () Strain differences in the laboratory rat — impact on the autonomic, behavioral, and biochemical response to cholinesterase inhibition. J. Toxicol. Environ. Health45, \par

Gosnell B. A. and Krahn D. D. () Morphine-induced feeding — a comparison of the Lewis and Fischer inbred rat strains. Pharmacol. Biochem. Behav.44, \par

Goto Y., Kakizaki M., and Masaki N. () Spontaneous diabetes produced by selective breeding of normal Wistar rats. Proc. Japan. Acad. Sci.51, \par

Gouyon B. A., Reyldesmars F., Leromancer M., Pigeon C., Lewin M. J. M., and Lehy T. () In-vivo effect of somatostatin analog, lanreotide, and/or GRP antagonist, BIM, on the growth of colon-cancer peritoneal carcinomatosis in the rat.

International Journal of Oncology7, \par

Gray J. E., van Zwieten M. J., and Hollander C. F. () Early light microscopic changes of chronic progressive nephrosis in several strains of aging laboratory rats. J. Gerontol.37, \par

Greenhouse D. D., Festing M. F. W., Hasan S., and Cohen A. L. () Catalogue of inbred strains of rats, in Genetic monitoring of inbred strains of rats (Hedrich H.

J., ed), pp. Gustav Fischer, Stuttgart, New York. (Gustav Fischer; Stuttgart, New York; N)\par

Greiner D. L. () T cell alloantigenic systems in the rat. Rat News Lett.13, \par

Greiner D. L., Handler E. S., Nakano K., Mordes J. P., and Rossini A. A. () Absence of the RT-6 T cell subset in diabetes-prone BB/W rats. J. Immunol., \par

Director, UCI Infectious Disease Science Initiative


Phone: ()
Email: [email protected]

University of California, Irvine
F Berk Hall
Mail Code:
Irvine, CA

Infectious disease epidemiology, drug-resistant tuberculosis, TB/HIV co-infection, molecular diagnostics, community-based intervention trials, molecular epidemiology, social determinants

Scholar Profile


Shin SS, Modongo C, Zetola NM.

Is twice-daily dolutegravir necessary for HIV/TB co-infected patients receiving rifampicin-based TB therapy? Clinical Infectious Diseases (In Press).

Shin SS, Carpenter C, Ekstrand M, Wang Q, Yadav K, Sinha S, Nyamathi AM. The effect of integrated nutritional interventions on children of women living with HIV in rural India: A factorial intervention trial. Clin Infect Dis ?guestAccessKey=aad1-eb8e-6c9b3d

Mupfumi L, Wang Q, Moyo S, Shin SS, Zetola NM, Nnawa N, Kgwaadira BT, Chebani T, Iketleng T, Mogashoa T, Musonda R, Kasvosve I, Gaseitsiwe S.

What is a ppd allergy

High Incidence of tuberculosis in the first six months in HIV-infected adults registered in the Botswana National Antiretroviral therapy programme between and AIDS (In Press).

Wang Q, Modongo C, Baik Y, Allender C, Engelthaler DM, Warren RM, Zetola NM, Shin SS. Utility of targeted, amplicon-based deep sequencing to detect resistance to first-line tuberculosis drugs in Botswana. Antimicrobial Agents and Chemotherapy AAC (). doi/AAC

Tawe L , MacDuffie E , Narasimhamurthy M , Wang Q , Gaseitsiwe S , Moyo S , Kasvosve I , Shin SS , Zetola NM , Paganotti GM , Grover S.

Human Papillomavirus (HPV) Genotypes in Women with Invasive Cervical Cancer with and without Human Immunodeficiency Virus (HIV) Infection in Botswana. International Journal of Cancer 0(ja). doi/ijc

Modongo C, Wang Q, Dima M, Ogopotse M, Kgwaadira B, Rankgoane — Pono G, Shin SS , Zetola NM. Clinical and virological outcomes of TB/HIV co — infected patients treated with dolutegravir — based HIV antiretroviral regimens: Early progra mmatic experience from Botswana .J Acquir Immune De?c Syndr.


Baik Y*, Fane O, Wang Q, Modongo C, Caiphus C, Zetola NM, Shin SS . Undetected tuberculosis at enrollment and after hospitalization in medical and oncology wards in Botswana. PLOS ONE . ;14(7):e doi/

Shin SS, Carpenter C, Ekstrand M, Wang Q, Grover S, Zetola NM, Yadav K, Sinha S, Nyamathi AM.

Cervical cancer screening and awareness survey among women living with HIV/AIDS in Rural Andhra Pradesh, India. Int J STD AIDS Feb doi: / NIHMS

Shin SS , Modongo C, Baik Y, Allende r C, Engelthaler DM, Warren RM , Zetola NM. Mixed infections are associated with poor treatment outcomes among newly diagnosed tuberculosis patients independent of pre — treatment heteroresistance .

Journal of Infectious Diseases 2 ; (12 ) — doi: /infdis/jiy PMCID: PMC

Nyamathi AM, Shin SS, Carpenter C, Garfin D, Yadav K, Sinha S, Ekstrand M. Title: Sustained Effect of a Community-based Behavioral and Nutrition Intervention on HIV-related Outcomes among Women living with HIV in Rural India: A Quasi-experimental Trial.

J Acquir Immune Defic Syndr. ;81(4)– PMCID: PMC

Sweetland AC, Galea J, Shin SS , Driver C, Dlodlo R, Karpati A, Wainberg ML on behalf of The Union TB & Mental Health Working Group. Global receptivity to TB and mental health service integration: A survey of National TB Program Directors. Int J Tuberc Lung Dis May 1;23(5) — PMCID: PMC

Grover S, Modongo C, Wang Q, Chiyapo SP, Nsingo-Bvochora M, Narasimhamurthy M, Lin LL, Jarvis J, Shin SS, Zetola NM.

HIV is not associated with initiation of curative treatment in women with cervical cancer in Botswana. Cancer ; doi: /cncr NIHMS

Shin SS, Carpenter CL, Ekstrand ML, et al. Household Food Insecurity as Mediator of the Association Between Internalized Stigma and Opportunistic Infections. AIDS Behav. June doi/s NIHMSID

Nyamathi AM, Salem BE, Ekstrand M, Yadav K, Le Y, Oleskowicz T, Shin SS. Correlates of Treatment Readiness Among Formerly Incarcerated Homeless Women.

Criminal Justice and Behavior. Jul 1;45(7)– NIHMS

Shin SS, Modongo C, Zetola NM, Wang Q, Phologolo T, Kestler M, Ho-Foster A. High rates of exposure to tuberculosis patients among HIV-infected healthcare workers in Botswana. Int J Tuberc Lung Dis ;22(4) PMCID: PMC

Shin SS, Modongo C, Boyd R, Caiphus C, Kuate L, Kgwaadira B, Zetola NM. High Treatment Success Rates among HIV-infected Multidrug-resistant Tuberculosis Patients after Expansion of Antiretroviral Therapy in Botswana, – J Acquir Immune Defic Syndr.

;74(1) PMCID: PMC

K01 AI National Institute of Allergy and Infectious Diseases — NIH (PI: Shin) The Effect of Mixed-strain M. tuberculosis Infections on Treatment Outcomes 2/1/ – 1/31/ Role: Principal Investigator

CRDF Global Indo-US Joint Program on HIV/AIDS and STI Prevention Research Collaboration Award (PI: Shin, Shrinivasa) The effect of HIV infection on molecular diagnostics for drug-resistant tuberculosis in India 10/08/ – 10/7/ Role: Co-PI

UCI Infectious Disease Science Initiative



Jeffrey S.

Berman, M.D.


  1. Irene L. Graham, M.D.
  2. Sharon E Frey, M.D.
  3. Rong Hou, M.D.
  4. Guangyong Peng, M.D., Ph.D.
  5. Sarah L. George, M.D.
  6. Ranjit Ray, Ph.D.
  7. Donald J. Kennedy, M.D.
  8. Getahun Abate, M.D., Ph.D.
  9. Dan Hoft, M.D., Ph.D.
  10. Claudia Castillo-Paredes, M.D.
  11. Jianguo Liu, M.D., Ph.D.
  12. Azra Blazevic, D.V.M., M.S.P.H.
  13. Geoffrey Gorse, M.D.
  14. Marcia L Sokol-Anderson, M.D.

Faculty and Fellows

[email protected]

Professor of Medicine
Director, Sarcoidosis Clinic, Boston Medical Center

Medical School: Case Western Reserve University,
Internship and Residency: Boston City Hospital
Fellowship: Boston University Medical Center

BU Profile for Dr.


Special Interests:


  1. New diagnostic tests
  2. Sarcoidosis
  3. Therapy of sarcoidosis
  4. Clinical characteristics of sarcoidosis
  5. Sarcoidosis in minority populations


I own had an interest in Pulmonary Immunology for over 20 years. I began by looking at basic mechanisms of lymphocyte accumulation in response to cytokine signals, and I own gradually turned my interest to clinical and translational research. In the past ten years I own divided my time between basic and translational investigations involving the novel cytokine, osteopontin, and clinical research involving patients with Sarcoidosis.

My interest in osteopontin (Opn) began upon hearing a report that OPN was the most prevalent message upregulated in macrophages upon exposure to mycobacterium.

It is an strange duck amongst cytokines, in that it is prominently expressed in bone and is involved in disparate processes such as bone remodeling, wound healing, inflammation, and tumor metastasis. I own been interested in the immunologic and inflammatory aspects of Opn, and my laboratory has been involved in research linking Opn to T cell function, granuloma formation and interstitial pulmonary fibrosis.

My interest in Sarcoidosis rose out of my year involvement in the Tuberculosis Clinic at the Boston City Hospital and an affiliated homeless shelter.

Viewing Sarcoidosis as a “companion” disease to TB, I was intrigued by the mysteries behind this granulomatous disease. I gradually built a Sarcoid population within the TB clinic and 10 years ago spun off my current Sarcoid Clinic. My colleague, Praveen Govender, and I see approximately new patients each year, some referred for second opinions and other referred for ongoing diagnosis or management. We own a number of clinical research projects ongoing, including diagnosis of cardiac disease, and management of calcium and bone metabolism in Sarcoidosis.

We share clinic space and collaborate with Dr. Liz Klings and the Pulmonary Hypertension Middle in the diagnosis and care of patients with Sarcoidosis who develop pulmonary arterial hypertension. We own been involved in a large national study of Sarcoidosis in African American women with Sarcoidosis.

Selected Publications:

Please see BU Profile for finish Publications list


The Sarcoidosis Clinic is located in the Doctor’s Office Building:

Harrison Avenue Suite
Boston, MA
Phone: ()
FAX: ()


The European Baseline Series consists of haptens based on the experience from numerous years of studies of frequencies of contact allergy performed by the European Environmental and Contact Dermatitis Research Group (EECDRG).
The series can be seen as a basic "standard" baseline series in case no specific country specific baseline series is offered.

Click here for hapten information in Russian.

Name Conc
1. PA Potassium dichromate % pet
3. Mx Thiuram stir % pet
4. N Neomycin sulfate % pet
5. CA Cobalt(II)chloride hexahydrate % pet

Mx Caine stir III % pet
7. NA Nickel(II)sulfate hexahydrate % pet
8. H 2-Hydroxyethyl methacrylate % pet
MxC Paraben stir % pet
I N-Isopropyl-N-phenylphenylenediamine (IPPD) % pet
MxA Mercapto stir % pet
E Epoxy resin, Bisphenol A % pet
B Peru balsam % pet
B 4-tert-Butylphenolformaldehyde resin (PTBP) % pet
MA 2-Mercaptobenzothiazole (MBT) % pet
Mx Fragrance stir I % pet
Mx Sesquiterpene lactone stir % pet
P Propolis % pet
BB Budesonide % pet
TB Tixocortolpivalate % pet
Mx Fragrance stir II % pet
Mx Textile dye stir % pet